Name: KU-32
Brand: TargetMol
SKU: T15671
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

25 mg

待询

3-6月

50 mg

待询

3-6月

100 mg

待询

3-6月

生物活性

产品描述	KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.
体外活性	KU-32 protects against glucose-induced death of embryonic DRG (dorsal root ganglia) neurons cultured for 3 days in vitro. Treating human islets with KU-32 for 24 hours displays no toxicity. KU-32 improves cellular viability by blocking apoptosis, with a minimum of 2-day exposure. When preincubate in KU-32, isolated human islets release more glucose-stimulated insulin [1] [2].
体内活性	Administered with KU-32 (10 weeks; diabetic BKS-db/db mice) do not display any obvious changes in blood glucose and insulin levels, despite having greater insulin staining/beta cells in the pancreas compared to untreated BKS db/db mice[1].

化学信息

分子量	407.41
分子式	C₂₀H₂₅NO₈
CAS No.	956498-70-7
Smiles	CC1=C2C(C=C(NC(C)=O)C(=O)O2)=CC=C1O[C@H]3[C@H](O)[C@H](O)[C@@H](OC)C(C)(C)O3
密度	1.37±0.1 g/cm3 (20 °C, 760 mmHg)