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Benzenesulfonamide
Synonyms: 苯磺酰胺, Phenyl sulfonamide, Benzosulfonamide, Benzenesulphonamide货号 T6781Cas号 98-10-2 一键复制产品信息纯度: 99.99%
很棒
很棒Benzenesulfonamide (Benzosulfonamide) 是碳酸酐酶的抑制剂。
Benzenesulfonamide
一键复制产品信息 很棒纯度: 99.99%
货号 T6781Cas号 98-10-2
别名 苯磺酰胺, Phenyl sulfonamide, Benzosulfonamide, Benzenesulphonamide
Benzenesulfonamide (Benzosulfonamide) 是碳酸酐酶的抑制剂。
其他形式的 “Benzenesulfonamide”:
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 1 g | ¥ 108 | 现货 | |
| 5 g | ¥ 198 | 现货 | |
| 10 g | ¥ 268 | 现货 | |
| 25 g | ¥ 396 | 现货 | |
| 1 mL x 10 mM (in DMSO) | ¥ 195 | 现货 |
库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单
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产品介绍
Benzenesulfonamide AI Summary
Benzenesulfonamide exhibits a diverse bioactivity profile, prominently characterized by its inhibitory effects on various carbonic anhydrase (CA) enzymes. It shows a strong binding affinity with human carbonic anhydrase II, exhibiting a log K value of 6.69. Its inhibitory activities include an IC50 value of 2000.0 nM against dog red blood cell carbonic anhydrase and a Ki value of 305.0 nM against human carbonic anhydrase 2. Additionally, it demonstrates antimicrobial properties against Malassezia species, with MIC values ranging from 160.0 to 320.0 μg/mL.
The compound has varied partition coefficients, indicating a complex balance between hydrophilicity and lipophilicity; logP values include -3.14 in dodecane, 0.33, and 0.31 in different assays. It also shows diuretic activity and displays thermal shift assay results with several human recombinant carbonic anhydrase enzymes, including CA13, CA12, CA7, CA2, and CA1. The binding affinity to Lp-PLA2 and inhibitory activity against human recombinant Lp-PLA2 are also noted, although with relatively high IC50 values. These multifaceted attributes suggest that Benzenesulfonamide has potential for further investigation in various biochemical and medical applications involving carbonic anhydrase and antimicrobial activities..
Note: Summary generated by AI. Data source: ChEMBL 
生物活性
化学信息
储存&溶解度
| 产品描述 | Benzenesulfonamide (Benzosulfonamide) ia an inhibitor of carbonic anhydrases. |
| 别名 | 苯磺酰胺, Phenyl sulfonamide, Benzosulfonamide, Benzenesulphonamide |
| 分子量 | 157.19 |
| 分子式 | C6H7NO2S |
| CAS No. | 98-10-2 |
| Smiles | NS(=O)(=O)C1=CC=CC=C1 |
| 密度 | 1.327g/cm3 |
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准 | |||||||||||||||||||||||||||||||||||
| 溶解度信息 | DMSO: 45 mg/mL (286.28 mM), Sonication is recommended.  Ethanol: 29 mg/mL (184.49 mM), Sonication is recommended. H2O: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。 | ||||||||||||||||||||||||||||||||||||
计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
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