Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cedazuridine (E7727) (Compound 7a) hydrochloride 是一种可用于研究癌症的,口服有效的胞苷脱氨酶 (CDA) 抑制剂 (IC 50 = 0.4 μM)。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 10-14周 | ||
50 mg | ¥ 13,800 | 10-14周 | ||
100 mg | ¥ 17,500 | 10-14周 |
Cedazuridine hydrochloride 的其他形式现货产品:
产品描述 | Cedazuridine (E7727) (Compound 7a) hydrochloride can be used for researching of cancer that is an orally active inhibitor of cytidine deaminase (CDA) (IC 50 = 0.4 μM) [1]. |
体外活性 | Cedazuridine (Compound 7a) exhibits superior acid stability [1]. Cedazuridine (0-10 μM; 72 h) does not enhance effects of AZA ( 5-Azacytidine) in growth inhibition of AML cell lines [2]. |
体内活性 | Cedazuridine (3 mg/kg; p.o.; daily for 7 days) in combination with 2.5 mg/kg AZA shows tumor regression in mice MOLM-13 CDX and PDX models [2]. Animal Model: Female NSGS mice, 6–8 weeks old, human cell line-derived (CDX) and primary patient-derived xenograft (PDX) models [2] Dosage: 3 mg/kg Administration: Oral administration, in combination with 2.5 mg/kg AZA, daily for 7 days Result: Led to reduction of leukemic expansion in combination with AZA in a cell line-derived xenograft transplantation, and exhibited preliminary safety and efcacy in a primary AML PDX model. Animal Model: NSGS male mice [2] Dosage: 1, 3, 10 and 30 mg/kg Administration: Oral, in combination with 2.5 mg/kg AZA (Pharmacokinetic Studies) Result: Dose-dependently increased the AUC of oral AZA and in comparison to dosing of standard i.p. AZA. |
分子量 | 304.68 |
分子式 | C9H15ClF2N2O5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Cedazuridine hydrochloride Inhibitor inhibitor inhibit