很棒GW791343 dihydrochloride (GW791343 (HCl)) 是有种属特异性的 P2X7变构调节剂，对人 P2X7的 pIC50为6.9-7.2。
很棒GW791343 dihydrochloride (GW791343 (HCl)) 是有种属特异性的 P2X7变构调节剂，对人 P2X7的 pIC50为6.9-7.2。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 1 mg | ¥ 198 | 现货 | |
| 5 mg | ¥ 493 | 现货 | |
| 10 mg | ¥ 696 | 现货 | |
| 25 mg | ¥ 1,450 | 现货 | |
| 50 mg | ¥ 2,150 | 现货 | |
| 100 mg | ¥ 2,970 | 现货 | |
| 1 mL x 10 mM (in DMSO) | ¥ 490 | 现货 |
| 产品描述 | GW791343 dihydrochloride (GW791343 (HCl)) is a P2X7 allosteric modulator. |
| 体外活性 | GW791343 were non-competitive inhibitors of human P2X(7) receptors.?Receptor protection studies using decavanadate and pyridoxalphosphate-6-azophenyl-2',4'-disulphonic acid (PPADS) showed that neither compound-17 nor GW791343 competitively interacted at the ATP binding site and so were probably negative allosteric modulators of the P2X(7) receptor.?GW791343 prevented the slowly reversible blockade of the human P2X(7) receptor produced by compound-17 and inhibited [(3)H]-compound-17 binding to the P2X(7) receptor suggesting they may bind to similar or interacting sites[1]. |
| 别名 | GW791343 (HCl) |
| 分子量 | 447.35 |
| 分子式 | C20H26Cl2F2N4O |
| CAS No. | 1019779-04-4 |
| Smiles | Cl.Cl.Cc1ccc(CN2CCNCC2)cc1NC(=O)CNc1ccc(F)c(F)c1 |
| 密度 | no data available |
| 存储 | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| 溶解度信息 | DMSO: 42 mg/mL (93.89 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||
DMSO
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 一共给药动物 10 只 ，您使用的配方为 5% 
DMSO+ 30%PEG300+ 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为 2 mg/mL 。 母液，添加 300 μLPEG300 混匀澄清，再加 50μLTween 80, 混匀澄清，再加 600μLSaline/PBS/ddH2O 混匀澄清 以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
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