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Btk inhibitor 2

Name: Btk inhibitor 2
Brand: TargetMol
SKU: T10629
Price: 315 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.94%

货号 T10629Cas号 1558036-85-3

别名 BGB-3111 analog

Btk inhibitor 2 (BGB-3111 analog) 是一种布鲁顿酪氨酸激酶 (BTK) 抑制剂。

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Btk inhibitor 2

一键复制产品信息

很棒

纯度: 99.94%

货号 T10629 别名 BGB-3111 analogCas号 1558036-85-3

Btk inhibitor 2 (BGB-3111 analog) 是一种布鲁顿酪氨酸激酶 (BTK) 抑制剂。

规格	价格	库存
1 mg	¥ 315	现货
5 mg	¥ 745	现货
10 mg	¥ 1,070	现货
25 mg	¥ 2,150	现货
50 mg	¥ 3,290	现货
100 mg	¥ 4,890	现货
1 mL x 10 mM (in DMSO)	¥ 692	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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资源下载:

COA LCMS HNMR HPLC 产品操作手册

产品介绍

Btk inhibitor 2 AI Summary

Btk inhibitor 2 shows potent bioactivity as a BTK inhibitor, demonstrating an IC50 of 0.17 nM for inhibiting recombinant BTK activity in a TR-FRET assay and an IC50 of 1.0 nM for reducing BTK phosphorylation at the Tyr223 residue in human Ramos cells when stimulated with pervanadate or Na3VO4. Additionally, this compound exhibits antiviral activity by inhibiting the SARS-CoV-2 3CL-Pro protease by 16.58% at a concentration of 20 µM in a FRET assay and shows an inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 µM after 48 hours at 0.01 MOI SARS-CoV-2 virus, with a measured inhibition of -0.27%. These results indicate its potential as a targeted therapy for BTK-related diseases and as an antiviral agent..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Btk inhibitor 2 (BGB-3111 analog) is a BTK inhibitor.
别名	BGB-3111 analog

化学信息

分子量	431.49
分子式	C₂₄H₂₅N₅O₃
CAS No.	1558036-85-3
Smiles	NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)[C@@H]1CCCN(C1)C(=O)C=C
密度	1.32 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 75 mg/mL (173.82 mM), Sonication and heating are recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.64 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3176 mL	11.5878 mL	23.1755 mL	115.8775 mL
5 mM	0.4635 mL	2.3176 mL	4.6351 mL	23.1755 mL
10 mM	0.2318 mL	1.1588 mL	2.3176 mL	11.5878 mL
20 mM	0.1159 mL	0.5794 mL	1.1588 mL	5.7939 mL
50 mM	0.0464 mL	0.2318 mL	0.4635 mL	2.3176 mL
100 mM	0.0232 mL	0.1159 mL	0.2318 mL	1.1588 mL