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4-CMTB

Name: 4-CMTB
Brand: TargetMol
SKU: T8642
Price: 495 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.59%

货号 T8642Cas号 300851-67-6

4-CMTB 是选择性的游离脂肪酸受体 2(FFA2/GPR43)的激动剂以及正变构调节剂 (pEC50=6.38)。

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4-CMTB

一键复制产品信息

很棒

纯度: 99.59%

货号 T8642Cas号 300851-67-6

4-CMTB 是选择性的游离脂肪酸受体 2(FFA2/GPR43)的激动剂以及正变构调节剂 (pEC50=6.38)。

规格	价格	库存
1 mg	¥ 495	现货
2 mg	¥ 718	现货
5 mg	¥ 1,210	现货
10 mg	¥ 1,810	现货
25 mg	¥ 3,130	现货
50 mg	¥ 4,480	现货
100 mg	¥ 6,330	现货
1 mL x 10 mM (in DMSO)	¥ 1,130	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.59%

颜色: 白色

性状: Solid

联系我们获取更多批次信息

资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

4-CMTB AI Summary

4-CMTB has agonist activity at the human FFA2 receptor expressed in CHO cells, inhibiting forskolin-induced cAMP production with an IC50 of 800.0 nM and showing an efficacy of 98.0% relative to acetate. Additionally, it has diverse bioactivities across various assays: it is cytotoxic to Streptococcus with an EC50 > 150000.0 nM and to SK(-)GAS Group A Streptococcus with an EC50 of 12662.0 nM; modulates Lamin A splicing with a potency of 11220.2 nM; and acts as an inhibitor of multiple targets including mitochondrial division or activator of mitochondrial fusion (35481.3 nM), ROR gamma transcriptional activity (19952.6 - 14125.4 nM), Streptokinase promotor activity (20387.0 nM), malarial parasite plastid (9285.0 - 3696.4 nM), HP1-beta chromodomain interactions (89125.1 nM), Polymerase Iota (89125.1 nM), TGF-b (1995.3 nM), Marburg Virus entry (6309.6 nM), Hepatitis C Virus (31622.8 nM), GLP-1 receptor inverse agonists (10000.0 nM), HIV-1 protein Vpr (56234.1 nM), human tyrosyl-DNA phosphodiesterase 1 (20596.2 nM), and EPAC2 (8912.5 nM). Moreover, it induces synthetic lethality in tumor cells producing 2HG with potencies ranging from 10322.5 nM to 9200.0 nM and shows antiviral activity against Foot and Mouth Disease Virus (35481.3 nM). In enzymatic assays for human HDAC6, it exhibits 10.39% inhibition with a commercial peptide substrate but a negative inhibition of -2.49% with a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	4-CMTB is a selective agonist of FFA2 and GPR43.It also is a positive allosteric modulator (pEC50=6.38).

化学信息

分子量	294.8
分子式	C₁₄H₁₅ClN₂OS
CAS No.	300851-67-6
Smiles	CC(C)C(C(=O)Nc1nccs1)c1ccc(Cl)cc1
密度	1.290 g/cm3 (Predicted)

储存&溶解度

存储

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 100 mg/mL (339.21 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (13.57 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3921 mL	16.9607 mL	33.9213 mL	169.6065 mL
5 mM	0.6784 mL	3.3921 mL	6.7843 mL	33.9213 mL
10 mM	0.3392 mL	1.6961 mL	3.3921 mL	16.9607 mL
20 mM	0.1696 mL	0.8480 mL	1.6961 mL	8.4803 mL
50 mM	0.0678 mL	0.3392 mL	0.6784 mL	3.3921 mL
100 mM	0.0339 mL	0.1696 mL	0.3392 mL	1.6961 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。