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3-Nitropropanoic acid

Name: 3-Nitropropanoic acid
Brand: TargetMol
SKU: T3009
Price: 168 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.94%

货号 T3009Cas号 504-88-1

别名 β-Nitropropionic acid, Bovinocidin, 3-硝基丙酸, 3-NP acid, 3-NP

3-Nitropropanoic acid (Bovinocidin) 是一种琥珀酸脱氢酶的不可逆抑制剂。它对分枝杆菌有很强的抗菌活性，MIC 值为 3.3μM。

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3-Nitropropanoic acid

一键复制产品信息

很棒

纯度: 99.94%

货号 T3009 别名 β-Nitropropionic acid, Bovinocidin, 3-硝基丙酸, 3-NP acid, 3-NPCas号 504-88-1

3-Nitropropanoic acid (Bovinocidin) 是一种琥珀酸脱氢酶的不可逆抑制剂。它对分枝杆菌有很强的抗菌活性，MIC 值为 3.3μM。

规格	价格	库存
25 mg	¥ 168	现货
50 mg	¥ 217	现货
100 mg	¥ 287	现货
200 mg	¥ 392	现货
500 mg	¥ 623	现货
1 g	¥ 883	现货
1 mL x 10 mM (in DMSO)	¥ 168	现货

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产品介绍

3-Nitropropanoic acid AI Summary

3-Nitropropanoic acid exhibits significant bioactivity across multiple domains, primarily as an inhibitor of isocitrate lyase (ICL) in various pathogenic microorganisms. Specifically, it demonstrates inhibitory effects against Candida albicans ICL with IC50 values ranging from 6,000.0 nM to 50,700.0 nM and antifungal activity with an IC50 value of 845,000.0 nM against Candida albicans ATCC 10231. In addition, it shows antimycobacterial activity against Mycobacterium tuberculosis H37Ra with a minimum inhibitory concentration (MIC) of 3,300.0 nM and also inhibits Mycobacterium tuberculosis ICL with varying degrees of inhibition, reporting an IC50 value of 11,600.0 nM. The compound targets other pathways as well, including modulation of various splicing activities, inhibition of the Menin-MLL interaction in leukemia, Bloom's syndrome helicase (BLM), and several other targets. While it also affects Magnaporthe grisea ICL with notable IC50 values, its cytotoxicity against mammalian cells and potential activity against SARS-CoV-2 suggest broader bioactivity profiles..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	3-Nitropropanoic acid (Bovinocidin) is an irreversible inhibitor of succinate dehydrogenase.
别名	β-Nitropropionic acid, Bovinocidin, 3-硝基丙酸, 3-NP acid, 3-NP

化学信息

分子量	119.08
分子式	C₃H₅NO₄
CAS No.	504-88-1
Smiles	OC(=O)CC[N+]([O-])=O
密度	1.393g/cm3
颜色	Yellow
物理性状	Solid

储存&溶解度

存储

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 247.5 mg/mL (2078.43 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (33.59 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	8.3977 mL	41.9886 mL	83.9772 mL	419.8858 mL
5 mM	1.6795 mL	8.3977 mL	16.7954 mL	83.9772 mL
10 mM	0.8398 mL	4.1989 mL	8.3977 mL	41.9886 mL
20 mM	0.4199 mL	2.0994 mL	4.1989 mL	20.9943 mL
50 mM	0.1680 mL	0.8398 mL	1.6795 mL	8.3977 mL
100 mM	0.0840 mL	0.4199 mL	0.8398 mL	4.1989 mL