规格

价格

库存

数量

5 mg

¥ 237

待询

10 mg

¥ 388

待询

25 mg

¥ 764

待询

50 mg

¥ 1,488

待询

100 mg

¥ 2,361

待询

1 mL x 10 mM (in DMSO)

¥ 248

现货

生物活性

产品描述	Flecainide acetate (R-818) is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias (abnormal fast rhythms of the heart).
体内活性	Flecainide（acetate）是一种有效的抗心律失常化合物，在口服时能够终止和控制儿童中相对难治的室上性心动过速，且不产生副作用[1]。
动物实验	A total of 8 infants were treated with flecainide for refractory tachyarrhythmia's. Diagnosis on electrocardiogram (ECG) was atrioventricular reentry tachycardia (AVRT) in 5, atrial ectopic tachycardia (AET) in 2, a combination of AVRT and atrioventricular nodal reentry tachycardia (AVNRT) in 1. All patients had failed trial of antiarrhythmic drugs prior to presentation: digoxin and propranolol in 7, amiodarone in 3, cardioversion in 1. Flecainide (80-130 mg/m(2) orally) resulted in termination of the tachycardia in all 8 patients. Acute pharmacological termination of arrhythmia occurred with oral flecainide loading in 1 and temporarily with intravenous esmolol loading in 1 patient. Adjuvant therapy in form of propranolol was used in 5 and digoxin in 2. There were no side effects noted. Four episodes of recurrence were noted in 3 patients over 2 years, all of which responded to dose increase. Mean follow up time is 24.75 months[1].
别名	氟卡胺, 醋酸洗必太, R-818, Flecainide (acetate)

化学信息

分子量	474.39
分子式	C₁₉H₂₄F₆N₂O₅
CAS No.	54143-56-5
Smiles	CC(O)=O.FC(F)(F)COc1ccc(OCC(F)(F)F)c(c1)C(=O)NCC1CCCCN1
密度	1.286g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 50 mg/mL (105.4 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.22 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1080 mL	10.5399 mL	21.0797 mL	105.3985 mL
5 mM	0.4216 mL	2.1080 mL	4.2159 mL	21.0797 mL
10 mM	0.2108 mL	1.0540 mL	2.1080 mL	10.5399 mL
20 mM	0.1054 mL	0.5270 mL	1.0540 mL	5.2699 mL
50 mM	0.0422 mL	0.2108 mL	0.4216 mL	2.1080 mL
100 mM	0.0211 mL	0.1054 mL	0.2108 mL	1.0540 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

Flecainide acetate

Flecainide acetate

产品介绍

引用文献

计算器

体内实验配液计算器

剂量转换

关键词

Flecainide acetate

Flecainide acetate