TAO Kinase inhibitor 1

Name: TAO Kinase inhibitor 1
Brand: TargetMol
SKU: T16987
Price: 171 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.74%

货号 T16987Cas号 850467-66-2

TAO Kinase inhibitor 1 是一种ATP 竞争性的thousand-and-one amino acid kinases (TAOK)选择性抑制剂，对于 TAOK1 和 TAOK2 的IC50s 分别为 11 nM 和 15 nM。它能够延迟有丝分裂以及诱导有丝分裂细胞死亡。

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TAO Kinase inhibitor 1

一键复制产品信息

很棒

纯度: 99.74%

货号 T16987Cas号 850467-66-2

规格	价格	库存
1 mg	¥ 171	现货
5 mg	¥ 391	现货
10 mg	¥ 598	现货
25 mg	¥ 1,300	现货
50 mg	¥ 2,050	现货
100 mg	¥ 2,990	现货
200 mg	¥ 4,250	现货
1 mL x 10 mM (in DMSO)	¥ 433	现货

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纯度: 99.74%

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产品介绍

TAO Kinase inhibitor 1 AI Summary

TAO Kinase inhibitor 1 inhibits human KIAA1361 kinase domain, human JIK kinase domain, and human TAO kinase domain, as evidenced by IC50 values below 50.0 nM in luciferase-luciferin coupled chemiluminescent kinase assays. It demonstrates a range of bioactivities, impacting cell viability across various cell lines, including HEK293T, U2OS, and human fibroblast cells, with growth rates ranging from negative to positive values. Additionally, thermal shift assays reveal that TAO Kinase inhibitor 1 affects protein stability, exhibiting both stabilizing (ΔTM up to 2.55°C) and destabilizing effects (ΔTM down to -5.93°C) on different protein domains, indicating its ability to interact with multiple regions of protein structures and potentially alter their conformation and function..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	TAO Kinase inhibitor 1 delays mitosis and induces mitotic cell death. TAO Kinase inhibitor 1 is a selective and ATP-competitive thousand-and-one amino acid kinases inhibitor (IC50s: 11 to 15 nM for TAOK1 and 2, respectively).
靶点活性	TAOK2:15 nM, TAOK1:11 nM

化学信息

分子量	384.47
分子式	C₂₅H₂₄N₂O₂
CAS No.	850467-66-2
Smiles	N(C(CNC(=O)C1=CC=C(C=C1)C2=CC=CC=C2)=O)C3C=4C(CCC3)=CC=CC4
密度	1.22 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (143.05 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.2 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6010 mL	13.0049 mL	26.0098 mL	130.0492 mL
5 mM	0.5202 mL	2.6010 mL	5.2020 mL	26.0098 mL
10 mM	0.2601 mL	1.3005 mL	2.6010 mL	13.0049 mL
20 mM	0.1300 mL	0.6502 mL	1.3005 mL	6.5025 mL
50 mM	0.0520 mL	0.2601 mL	0.5202 mL	2.6010 mL
100 mM	0.0260 mL	0.1300 mL	0.2601 mL	1.3005 mL