Saccharin

Name: Saccharin
Brand: TargetMol
SKU: T0889
Price: 131 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 98.51%

货号 T0889Cas号 81-07-2

别名 糖精, Saccharimide, O-Sulfobenzimide, O-Benzoic sulfimide, Benzoic sulfimide

Saccharin (O-Sulfobenzimide) 是一种口服有效的人造甜味剂，具有抑菌和微生物调节特性。

Saccharin

一键复制产品信息

很棒

纯度: 98.51%

货号 T0889 别名 糖精, Saccharimide, O-Sulfobenzimide, O-Benzoic sulfimide, Benzoic sulfimideCas号 81-07-2

Saccharin (O-Sulfobenzimide) 是一种口服有效的人造甜味剂，具有抑菌和微生物调节特性。

规格	价格	库存
50 mg	¥ 131	现货
100 mg	¥ 173	现货
500 mg	¥ 373	现货
1 g	¥ 539	现货
5 g	¥ 1,260	现货
1 mL x 10 mM (in DMSO)	¥ 195	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 98.51%

联系我们获取更多批次信息

资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Saccharin AI Summary

Saccharin exhibits multiple bioactivities across various biological targets. It demonstrates significant hypolipidemic activity in CF1 male mice, reducing serum triglycerides by 51% at a dosage of 20 mg/kg on the 14th day and lowering serum cholesterol by 68% on the 9th day and by 67% on the 16th day. It potentiates sweet taste with an intensity parameter of 1.0 relative to 10% sucrose and shows potent sweetness with potency values of 300 on a weight basis and 180 on a molar basis at 330 ppm. Despite this, it also exhibits some bitterness with a sensory score of 12.0. Regarding its activity as a carbonic anhydrase inhibitor, Saccharin displays varying inhibitory potencies against different isoforms. It inhibits human carbonic anhydrase 1 and 2 with Ki values of 18,540 nM and 5,950 nM, respectively. Notably, it exhibits strong inhibition against carbonic anhydrase 9 with a Ki of 103.0 nM and carbonic anhydrase 7 with a Ki of 10.0 nM. Additionally, it shows moderate inhibition against other isoforms such as carbonic anhydrase 12 (Ki = 633.0 nM). Its broad spectrum also includes inhibiting carbonic anhydrase from various organisms like Porphyromonas gingivalis, Trypanosoma cruzi, and Streptococcus mutans. In antiviral assays, Saccharin demonstrated activity against SARS-CoV-2, inhibiting viral-induced cytotoxicity in Caco-2 and VERO-6 cells. However, its efficacy varied with an IC50 value greater than 20,000 nM. Additionally, it showed a 37.77% inhibition of SARS-CoV-2-induced cytotoxicity at 10 μM after 48 hours. This compound also displays drug-like properties, such as an oral bioavailability of 84.0% in humans, a rapid elimination half-life of 1.11 hours, and a Cmax of 163,327.69 nM in ICR mice at a 30 mg/kg dose. Despite its diverse bioactivities, Saccharin exhibits no anti-inflammatory activity and presents moderate liver toxicity markers, indicating a need for careful consideration in therapeutic contexts..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Saccharin (O-Sulfobenzimide) is a flavoring agent and non-nutritive sweetener.
别名	糖精, Saccharimide, O-Sulfobenzimide, O-Benzoic sulfimide, Benzoic sulfimide

化学信息

分子量	183.18
分子式	C₇H₅NO₃S
CAS No.	81-07-2
Smiles	O=C1NS(=O)(=O)C2=CC=CC=C12
密度	0.793 g/cm3. Temperature:20 °C.

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 60 mg/mL (327.55 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.92 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.4591 mL	27.2956 mL	54.5911 mL	272.9556 mL
5 mM	1.0918 mL	5.4591 mL	10.9182 mL	54.5911 mL
10 mM	0.5459 mL	2.7296 mL	5.4591 mL	27.2956 mL
20 mM	0.2730 mL	1.3648 mL	2.7296 mL	13.6478 mL
50 mM	0.1092 mL	0.5459 mL	1.0918 mL	5.4591 mL
100 mM	0.0546 mL	0.2730 mL	0.5459 mL	2.7296 mL