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CAY10698

Name: CAY10698
Brand: TargetMol
SKU: T8950
Price: 208 CNY
Availability: InStock
Rating: 5 (10 reviews)

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纯度: 98.97%

货号 T8950Cas号 684236-01-9

CAY10698 是选择性的12-Lipoxygenase (12-LOX)抑制剂，IC50=5.1 μM。它对 5-LOX、15-LOX-1、15-LOX-2 和 COX-1/2 无活性。

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CAY10698

一键复制产品信息

很棒

纯度: 98.97%

货号 T8950Cas号 684236-01-9

CAY10698 是选择性的12-Lipoxygenase (12-LOX)抑制剂，IC50=5.1 μM。它对 5-LOX、15-LOX-1、15-LOX-2 和 COX-1/2 无活性。

规格	价格	库存
1 mg	¥ 208	现货
5 mg	¥ 467	现货
10 mg	¥ 798	现货
25 mg	¥ 1,670	现货
50 mg	¥ 2,490	现货
100 mg	¥ 3,550	现货
200 mg	¥ 4,870	现货
1 mL x 10 mM (in DMSO)	¥ 548	现货

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COA HNMR LCMS 产品操作手册

产品介绍

CAY10698 AI Summary

CAY10698 exhibits a range of bioactivities. It is a potent lipid storage modulator in Drosophila S3 cells (4.6 nM) and an inhibitor of the 12-human lipoxygenase (12-hLO) enzyme with varying potencies (15848.9 nM to 46000.0 nM). Additionally, it inhibits the ERK signaling pathway (15848.9 nM) and human alpha-Glucosidase cleavage of glycogen (5623.4 nM). It is an antagonist of EPAC2 (56234.1 nM) and displays antiviral activity against Foot and Mouth Disease Virus (1778.3 nM). It inhibits the malarial parasite plastid at 96 hours (1651.1 nM) and 48 hours (7375.3 nM), and modulates Lamin A splicing. Furthermore, it inhibits ALDH1A1 (39810.7 nM), BAZ2B (707.9 nM), TGF-b (11220.2 nM), and acts as an inverse agonist of the GLP-1 Receptor (12589.3 nM). Notably, it inhibits the human platelet 12-LOX enzyme (5100.0 nM) but does not significantly inhibit other related enzymes like human reticulocyte 15-LOX1, human 5-LOX, and human epithelial 15-LOX2 with IC50 values greater than 50,000.0 nM, 200,000.0 nM, and 40,000.0 nM respectively..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	CAY10698 is a 12-lipoxygenase inhibitor (12-LO; IC50 of 5.1 μM).
靶点活性	12-LOX:5.1 µM

化学信息

分子量	391.46
分子式	C₁₇H₁₇N₃O₄S₂
CAS No.	684236-01-9
Smiles	COc1cccc(CNc2ccc(cc2)S(=O)(=O)Nc2nccs2)c1O
密度	1.483 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 45 mg/mL (114.95 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.11 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5545 mL	12.7727 mL	25.5454 mL	127.7270 mL
5 mM	0.5109 mL	2.5545 mL	5.1091 mL	25.5454 mL
10 mM	0.2555 mL	1.2773 mL	2.5545 mL	12.7727 mL
20 mM	0.1277 mL	0.6386 mL	1.2773 mL	6.3863 mL
50 mM	0.0511 mL	0.2555 mL	0.5109 mL	2.5545 mL
100 mM	0.0255 mL	0.1277 mL	0.2555 mL	1.2773 mL