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- 755个核受体作用化合物的独特集合，可用于高通量筛选和高内涵筛选；
- 提供产品的来源、化学信息和生物学信息，为筛选提供理论方向和研究基础；
- 结构多样，药效显著，可渗透细胞；
- NMR和HPLC技术保证产品高纯度。
核受体化合物库
Nuclear Receptor Compound Library
很棒核受体是细胞内一类区别于膜受体的蛋白，它们与相应配体结合后，能够直接与基因组DNA 结合并调节相邻基因表达，因此这类受体被归类为转录因子。核受体在胚胎发育和机体内环境平衡中发挥关键作用。近年来，核受体家族在代谢性疾病领域受到广泛的关注，已有研究证明，它们与糖尿病、脂肪肝等疾病的发生发展密切相关，也被称为代谢性核受体。
TargetMol 汇集了755 种有文献报道的核受体相关化合物，适用于核受体相关信号通路及疾病研究，可用于高通量筛选和高内涵筛选。
TargetMol 的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。
资源下载
化合物库相关信息
Excel
SDF
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核受体化合物库规格
- 1 mg
- 10 μL x 10 mM (in DMSO)
- 20 μL x 10 mM (in DMSO)
- 30 μL x 10 mM (in DMSO)
- 50 μL x 10 mM (in DMSO)
- 100 μL x 10 mM (in DMSO)
- 250 μL x 10 mM (in DMSO)
询价 & 定制
产品描述
包装和储存
- 可选用DMSO耐受的96/384孔板或2D 条形码编码管；
- 干粉蓝冰运输，DMSO溶液干冰运输；
- 排布：96孔板：1st & 12th 空白对照，384孔板：1st & 2nd & 23th & 24th空白对照。
- 本化合物库通常以 DMSO 10 mM 浓度提供。少量产品可能因溶解性或稳定性需求，采用其他溶剂或浓度包装，具体以实际产品信息为准。
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化合物库组成
PPAR
Estrogen Receptor/ERR
Estrogen/progestogen Receptor
Androgen Receptor
Glucocorticoid Receptor
Apoptosis
Autophagy
Endogenous Metabolite
Antibacterial
ROS
Thyroid hormone receptor(THR)
Retinoid Receptor
FXR
NF-κB
Liver X Receptor
ROR
Progesterone Receptor
COX
Interleukin
Cytochromes P450
Akt
Reactive Oxygen Species
Drug Metabolite
ERK
Antifungal
Prostaglandin Receptor
AMPK
NR4A
Caspase
NO Synthase
TNF
p38 MAPK
JNK
IL Receptor
Ferroptosis
Parasite
PI3K
MMP
PROTACs
Antibiotic
Nrf2
Potassium Channel
Antioxidant
REV-ERB
GSK-3
STAT
RAR/RXR
Wnt/beta-catenin
Bcl-2 Family
Reductase
Mitophagy
Calcium Channel
TGF-beta/Smad
HSP
SARS-CoV
AChR
Dehydrogenase
TRP/TRPV Channel
PKC
Fatty Acid Synthase
Influenza Virus
Phosphatase
Tyrosinase
GPCR19
GPCR
HIV Protease
CDK
Adrenergic Receptor
Annexin A
NOS
PDE
TLR
mTOR
Sirtuin
GABA Receptor
ADC Cytotoxin
Glucosidase
Phospholipase
CaMK
transporter
Antifection
Cannabinoid Receptor
p53
VEGFR
Ras
HIF/HIF Prolyl-Hydroxylase
Virus Protease
glycosidase
IGF-1R
PARP
Lipoxygenase
Integrin
RAAS
Smo
JAK
Epigenetic Reader Domain
IκB/IKK
FOXO
DNA/RNA Synthesis
5-HT Receptor
Anti-infection
DNA Methyltransferase
AhR
MRP
Microtubule Associated
FAK
Glutathione Peroxidase
FABP
LRRK2
Acetyl-CoA Carboxylase
Ligands for Target Protein for PROTAC
Gamma-secretase
Angiotensin-converting Enzyme (ACE)
Orphan Receptor
Complement System
Src
HBV
iGluR
ABC Transporter
Cholinesterase (ChE)
c-Myc
EGFR
Histone Acetyltransferase
Aromatase
MDM-2/p53
Sodium Channel
FOXO3
Proteasome
PKA
FLAP
Hedgehog/Smoothened
TAM Receptor
Liposome
BACE
IFNAR
Raf
Phosphorylase
Bombesin Receptor
Lipid
PSMA
Beta Amyloid
PDK
MEK
FLT
c-Kit
BMI-1
Thrombin
NOD-like Receptor (NLR)
Histone Methyltransferase
Adenylate cyclase
UGT
Ligands for E3 Ligase
PGE Synthase
Survivin
FGFR
HMG-CoA Reductase
HCV Protease
MyD88
Arrestin
Melatonin Receptor
Cysteine Protease
Leukotriene Receptor
Aryl Hydrocarbon Receptor
Prolyl Endopeptidase (PREP)
Topoisomerase
LDL
Opioid Receptor
Xanthine Oxidase
Epoxide Hydrolase
Huntingtin
P-gp
Pyroptosis
FKBP
MicroRNA
Serine Protease
Glucokinase
Immunology/Inflammation related
Glucagon Receptor
Mitochondrial Metabolism
Syk
S1P Receptor
ATPase
Carbonic Anhydrase
Histone Demethylase
PERK
HSV
GluR
DNA
Kras
Hydroxylase
Sigma receptor
c-Met/HGFR
gp120/CD4
GNRH Receptor
Photosensitizer
MAO
PAK
cAMP
Ephrin Receptor
CPT
Gap Junction Protein
NOD
Vitamin
Keywords
孕激素受体盐皮质激素受体炎症雄激素受体维甲酸受体维甲酸X受体糖皮质激素受体内分泌疾病甲状腺激素受体化合物库核受体药物发现核受体化合物库核受体核激素受体高通量筛选代谢疾病雌激素受体癌症Transcriptional regulationTRThyroid hormone receptorSmall molecule compoundsRXRRetinoid X receptorRetinoic acid receptorRARPXRProgesterone receptorPRPPARNuclear Receptor Inhibitors Librarynuclear receptor inhibitor libraryNuclear receptor drug discoveryNuclear receptorNuclear hormone receptorMRMineralocorticoid receptorMetabolic diseaseLXRInflammationHigh-throughput screeningGRGlucocorticoid receptorFXREstrogen receptorERCompound libraryCARCancerARAndrogen receptor
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