Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CAY10746 是一种选择性 Rho 激酶 (ROCK) 抑制剂,对 ROCK I、ROCK II 具有抑制作用,IC50 值分别为 0.014 μM 和 0.003 μM。CAY10746 可用于研究糖尿病和视网膜病变。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,830 | 现货 | ||
5 mg | ¥ 4,570 | 现货 | ||
10 mg | ¥ 6,560 | 现货 | ||
25 mg | ¥ 9,830 | 现货 | ||
50 mg | ¥ 13,200 | 现货 | ||
100 mg | ¥ 17,900 | 现货 | ||
500 mg | ¥ 35,800 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 4,590 | 现货 |
产品描述 | CAY10746 is a selective Rho kinase (ROCK) inhibitor that inhibits ROCK I and ROCK II with IC50 values of 0.014 μM and 0.003 μM, respectively.CAY10746 can be used to study diabetic retinopathy. |
靶点活性 | ROCKI:14 nM, ROCKII:3 nM |
体外活性 |
CAY10746 (0.1-10 µM) inhibits phosphorylation of the ROCK target protein MYPT1 in SH-SY5Y cells and also inhibits the migration of human umbilical vein endothelial cells (HUVECs).[1] CAY10746 (1 µM) protects isolated mouse retinal neurons from apoptosis and oxidative stress induced by high glucose in an in vitro model of diabetic retinopathy. It also promotes high glucose-induced vessel regression in mouse retinal explants.[1] CAY10746 is an inhibitor of Rho-associated kinase I (ROCK-I) and ROCK-II (IC50s = 14 and 3 nM, respectively).[1] |
分子量 | 457.48 |
分子式 | C26H23N3O5 |
CAS No. | 2247240-76-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 75.0 mg/mL (163.9 mM), Sonication and heating to 60℃ are recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.1859 mL | 10.9294 mL | 21.8589 mL | 54.6472 mL |
5 mM | 0.4372 mL | 2.1859 mL | 4.3718 mL | 10.9294 mL | |
10 mM | 0.2186 mL | 1.0929 mL | 2.1859 mL | 5.4647 mL | |
20 mM | 0.1093 mL | 0.5465 mL | 1.0929 mL | 2.7324 mL | |
50 mM | 0.0437 mL | 0.2186 mL | 0.4372 mL | 1.0929 mL | |
100 mM | 0.0219 mL | 0.1093 mL | 0.2186 mL | 0.5465 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
CAY10746 2247240-76-0 Cell Cycle/Checkpoint Cytoskeletal Signaling Stem Cells ROCK CAY 10746 CAY-10746 Inhibitor inhibitor inhibit