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顶部相关产品产品介绍化学信息储存和溶解信息计算器

Indole-3-carbinol

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纯度: 98.59%

货号 T2947Cas号 700-06-1

别名 吲哚-3-甲醇, Indole-3-Methanol, I3C, 3-吲哚甲醇, 3-Indolemethanol

Indole-3-carbinol (I3C) 是樟子松中的一种天然产物，是可口服的硫代葡萄糖苷葡糖苷酶裂解产物。它是芳烃受体 (AhR) 的激动剂，可抑制 NF-κB 和 IκBα 激酶活化。

Indole-3-carbinol

Indole-3-carbinol

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Rating icon 很棒

纯度: 98.59%

货号 T2947 别名 吲哚-3-甲醇, Indole-3-Methanol, I3C, 3-吲哚甲醇, 3-IndolemethanolCas号 700-06-1

Indole-3-carbinol (I3C) 是樟子松中的一种天然产物，是可口服的硫代葡萄糖苷葡糖苷酶裂解产物。它是芳烃受体 (AhR) 的激动剂，可抑制 NF-κB 和 IκBα 激酶活化。

规格价格库存数量
1 g
¥ 247
现货
5 g
¥ 496
现货
10 g
¥ 868
现货
1 mL x 10 mM (in DMSO)
¥ 272
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产品介绍

生物活性
产品描述
Indole-3-carbinol (I3C), a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase activation.
别名吲哚-3-甲醇, Indole-3-Methanol, I3C, 3-吲哚甲醇, 3-Indolemethanol
化学信息
分子量147.17
分子式C9H9NO
CAS No.700-06-1
SmilesC(O)C=1C=2C(NC1)=CC=CC2
密度1.1135 g/cm3 (Estimated)
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
DMSO: 250 mg/mL (1698.72 mM), Sonication is recommended.
Ethanol: 28 mg/mL (190.26 mM), Sonication is recommended.
H2O: 7 mg/mL (47.56 mM), Sonication is recommended.
体内实验配方
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (6.79 mM), Sonication is recommended.
请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。
溶液配制表
H2O/Ethanol/DMSO
1mg5mg10mg50mg
1 mM6.7949 mL33.9743 mL67.9486 mL339.7432 mL
5 mM1.3590 mL6.7949 mL13.5897 mL67.9486 mL
10 mM0.6795 mL3.3974 mL6.7949 mL33.9743 mL
20 mM0.3397 mL1.6987 mL3.3974 mL16.9872 mL
Ethanol/DMSO
1mg5mg10mg50mg
50 mM0.1359 mL0.6795 mL1.3590 mL6.7949 mL
100 mM0.0679 mL0.3397 mL0.6795 mL3.3974 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
TargetMol | Animal experiments 比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments 一共给药动物10只，您使用的配方为5%TargetMol | reagent DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent （ 母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法: 取 50μLDMSOTargetMol | reagent 母液，添加 300 μLPEG300TargetMol | reagent 混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline/PBS/ddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ， 玉米油 等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

TargetMol AI Summary
Indole-3-carbinol demonstrates a diverse range of bioactivities and potential therapeutic applications across various biological targets and pathways. It shows notable sulfonation activity against Arylsulfotransferase (AST IV), with an apparent Michaelis constant (Km) of 29000.0 nM, a maximum velocity (Vmax) of 33.2 nM min^-1, and a catalytic efficiency (kcat/Km) of 38.9. The compound exhibits inhibitory properties in numerous enzymatic and cellular assays such as Schistosoma Mansoni Peroxiredoxins, Anthrax Lethal Toxin Internalization, AmpC Beta-Lactamase, and several other targets related to disease processes. Additionally, it inhibits the uptake of sodium fluorescein in OATP1B1 and OATP1B3-transfected CHO cells, showing substantial inhibition rates of 88.32% and 121.9%, respectively, at 10 µM. In antifungal assays, Indole-3-carbinol inhibits the mycelial growth of Leptosphaeria maculans on potato dextrose agar with increasing inhibitory percentages at higher concentrations: 19.0% at 0.10 mM, 27.0% at 0.20 mM, and 52.0% at 0.50 mM, with a half-life of more than 72 hours in water. It also exhibits mild inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) at a concentration of 2 mg/ml, showing 4.82% and 9.11% inhibition, respectively. The compound shows antiproliferative and cytotoxic activities against several human cell lines, including U87MG and 1321N1, with IC50 values of 526,000.0 nM and 309,000.0 nM respectively, and against IN1472, U251, U87, IN1528, and IN1760 cells, with EC50 values ranging from 290,000 nM to 1,580,000 nM. Furthermore, Indole-3-carbinol demonstrates antiviral activity, inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells at various concentrations, showing inhibition rates up to 1.16%. However, its inhibitory activity on SARS-CoV-2 3CL-Pro protease at 20 µM exhibits inconsistent results, with percentages of -27.37% and 5.975%. Lastly, Indole-3-carbinol also acts as an HDAC6 inhibitor, with inhibition percentages of 2.93% and 1.64% in enzymatic assays with commercial and custom peptide substrates, respectively. This suggests its potential utility across multiple disease models and therapeutic areas..
Note: Summary generated by AI, AI may be wrong some times, we do not provide any medical advice and only sell our product to accredited institution, Please cross-check with other sources, data source: chembl

关键词

Ubiquitin ligaseUbiquitin conjugating enzymeUbiquitin activating enzymep53Nuclear factor-κBNuclear factor-kappaBNF-κBNFκBNF-kBNFkBInhibitorinhibitIndole-3-carbinolIndole3carbinolIndole 3 carbinolEndogenousMetaboliteEndogenous MetaboliteE3EnzymeE3 ligating enzymeE3 EnzymeE2EnzymeE2 EnzymeE2 conjugating enzymeE1EnzymeE1/E2/E3 EnzymeE1 EnzymeE1 activating enzymeArylHydrocarbonReceptorAryl Hydrocarbon ReceptorAhR
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