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Phenacetin

Name: Phenacetin
Brand: TargetMol
SKU: T0778
Price: 136 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.98%

货号 T0778Cas号 62-44-2

别名 非那西丁, Acetophenetidin

Phenacetin (Acetophenetidin) 是一种非阿片类解热化合物，可用于缓解疼痛的研究。它是一种选择性的COX-3抑制剂，能作为人肝微粒体和大鼠体内 CYP1A2 的探针。

Phenacetin

一键复制产品信息

很棒

纯度: 99.98%

货号 T0778 别名 非那西丁, AcetophenetidinCas号 62-44-2

规格	价格	库存
100 mg	¥ 136	现货
500 mg	¥ 285	现货
1 g	¥ 358	现货
5 g	¥ 575	现货
1 mL x 10 mM (in DMSO)	¥ 358	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.98%

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

生物活性

产品描述	Phenacetin (Acetophenetidin) is a phenylacetamide that was formerly used in ANALGESICS but nephropathy and METHEMOGLOBINEMIA led to its withdrawal from the market.
靶点活性	COX-3:102 μM (IC50)
别名	非那西丁, Acetophenetidin

化学信息

分子量	179.22
分子式	C₁₀H₁₃NO₂
CAS No.	62-44-2
Smiles	N(C(C)=O)C1=CC=C(OCC)C=C1
密度	1.099 g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 125 mg/mL (697.47 mM), Sonication is recommended.

Ethanol: 34 mg/mL (189.71 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (11.16 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.5797 mL	27.8987 mL	55.7973 mL	278.9867 mL
5 mM	1.1159 mL	5.5797 mL	11.1595 mL	55.7973 mL
10 mM	0.5580 mL	2.7899 mL	5.5797 mL	27.8987 mL
20 mM	0.2790 mL	1.3949 mL	2.7899 mL	13.9493 mL
50 mM	0.1116 mL	0.5580 mL	1.1159 mL	5.5797 mL
100 mM	0.0558 mL	0.2790 mL	0.5580 mL	2.7899 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments

一共给药动物10只，您使用的配方为5% TargetMol | reagent

DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline /PBS/ddH₂O，那么您的工作液浓度为2mg/mL。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline /PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

TargetMol AI Summary

Phenacetin exhibits a diverse array of bioactivities and pharmacokinetic properties. It demonstrates an intrinsic aqueous solubility at pH 10 with a logS0 value of -2.48 and an octanol-water partition coefficient (logP) ranging from 1.45 to 1.58, indicating moderate lipophilicity. The compound inhibits the recombinant human AKR1C3 enzyme at 50 µM with a 10.0% inhibition rate and shows significant inhibition of human CYP1A2 activity with an IC50 value of 4.9 nM. Pharmacokinetically, Phenacetin has a half-life of 0.92 hours in humans after intravenous administration, a mean residence time of 1.1 hours, and a volume of distribution at steady-state of 1.4 L/kg. The clearance rate in humans is 21.0 mL/min/kg. The compound also shows good permeability across human Caco-2 cells, with logPapp values of -4.59 and -4.49, indicating efficient transport characteristics. In terms of hepatic metabolism, Phenacetin exhibits moderate clearance rates—19.2 mL/min/kg in human hepatocytes (logCL = 1.283) and shows intrinsic clearance in both human and rat liver microsomes. It also exhibits moderate to high metabolic stability, with a half-life of 0.4417 hours in human liver microsomes at 100 µM. Additionally, the compound demonstrates inhibitory effects on drug transporters, including OATP1B1 and OATP1B3, with significant inhibition rates of 55.67% and 98.3%, respectively. Phenacetin has shown moderate hepatotoxicity characterized by elevated serum ALT, AST, and ALP, indicative of potential liver damage. Furthermore, it displays a DILI positive/negative value of 1.0, suggesting propensity for drug-induced liver injury. It shows substrate activity at AADAC enzyme and various cytochrome P450 enzymes, including CYP1A2 and CYP46A1, with increased cholesterol hydroxylation by CYP46A1 observed at 43 µM. Additionally, the compound exerts antiviral activity against SARS-CoV-2, showing inhibition of induced cytotoxicity in VERO-6 cells and Caco-2 cells, although with limited potency and high IC50 values. Finally, Phenacetin does not inhibit human BSEP, MRP2, MRP3, or MRP4 significantly, with IC50 values exceeding 133,000 nM. Its overall bioactivity profiles suggest involvement in diverse biological pathways and potential therapeutic applications, albeit with considerations for hepatotoxic risks and moderate metabolic clearance rates..

Note: Summary generated by AI, AI may be wrong some times, we do not provide any medical advice and only sell our product to accredited institution, Please cross-check with other sources, data source: chembl