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gp120/CD4

gp120/CD4

In molecular biology, CD4 (cluster of differentiation 4) is a glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). CD4 is found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells. Envelope glycoprotein GP120 (or gp120) is a glycoprotein exposed on the surface of the HIV envelope. The 120 in its name comes from its molecular weight of 120 kDa. Gp120 is essential for virus entry into cells as it plays a vital role in attachment to specific cell surface receptors. These receptors are DC-SIGN, Heparan Sulfate Proteoglycan and a specific interaction with the CD4 receptor, particularly on helper T-cells. Binding to CD4 induces the start of a cascade of conformational changes in gp120 and gp41 that lead to the fusion of the viral membrane with the host cell membrane. Binding to CD4 is mainly electrostatic although there are van der Waals interactions and hydrogen bonds.
TargetMol
Cat. No. Product Name CAS No. Purity Chemical Structure
T35388 Anti-mouse CD4-InVivo
Anti-mouse CD4-InVivo
98%
Anti-mouse CD4-InVivo
Anti-mouse CD4-InVivo 一种抗小鼠 CD4 抗体抑制剂,可用于生命科学领域的相关研究,其产品编号为 T35388。
TN4778 Physalin H
化合物 TN4778
70241-09-7 98%
TargetMol Chemical Structure Physalin H
Physalin H is an Hh signaling inhibitor blocks GLI1-DNA-complex formation, it also strong quinone reductase induction activity with IR (Induction ratio, QR induc...
TN4130 Germacrone 4,5-epoxide
化合物 TN4130
92691-35-5 98%
TargetMol Chemical Structure Germacrone 4,5-epoxide
(4S,5S)-(+)-Germacrone-4,5-epoxide inhibits certain subtypes of cytochrome P450 (CYP).
T6418 BMS-378806
化合物BMS378806
357263-13-9 99.31%
TargetMol Chemical Structure BMS-378806
BMS-378806 (BMS-806) 是一种 HIV-1 抑制剂,可选择性抑制 HIV-1 gp120 结合到 CD4 受体,EC50为 0.85-26.5 nM。
TN1047 Ingenol mebutate
巨大戟醇甲基丁烯酸酯
75567-37-2 99.04%
TargetMol Chemical Structure Ingenol mebutate
Ingenol mebutate (Ingenol 3-Angelate) 是 PKC 的有效激动剂,包括 PKC-α、PKC-β、PKC-γ、PKC-δ 和 PKC-ε,Kis 为 0.3、0.105、0.162、0.376 和 0.171 nM。 Ingenol mebutate 具有抗炎和抗肿瘤活性。
T6256 YYA-021
化合物YYA021
144217-65-2 95.82%
TargetMol Chemical Structure YYA-021
YYA-021具有高抗HIV 活性和低细胞毒性,是一种抑制HIV 进入的小分子CD4模拟物,。
TN4583 Moringin
辣木籽素
73255-40-0 98%
TargetMol Chemical Structure Moringin
Moringin 是一种异硫氰酸酯,由 Moringa oleifera 种子中存在的硫代葡萄糖苷前体 glucoMoringin 通过黑芥子酶介导水解获得。Moringin 具有抗炎和抗氧化特性。
Anti-mouse CD4-InVivo
T35388
Anti-mouse CD4-InVivo 一种抗小鼠 CD4 抗体抑制剂,可用于生命科学领域的相关研究,其产品编号为 T35388。
Physalin H
TN4778
Physalin H is an Hh signaling inhibitor blocks GLI1-DNA-complex formation, it also strong quinone reductase induction activity with IR (Induction ratio, QR induc...
Germacrone 4,5-epoxide
TN4130
(4S,5S)-(+)-Germacrone-4,5-epoxide inhibits certain subtypes of cytochrome P450 (CYP).
BMS-378806
T6418
BMS-378806 (BMS-806) 是一种 HIV-1 抑制剂,可选择性抑制 HIV-1 gp120 结合到 CD4 受体,EC50为 0.85-26.5 nM。
Ingenol mebutate
TN1047
Ingenol mebutate (Ingenol 3-Angelate) 是 PKC 的有效激动剂,包括 PKC-α、PKC-β、PKC-γ、PKC-δ 和 PKC-ε,Kis 为 0.3、0.105、0.162、0.376 和 0.171 nM。 Ingenol mebutate 具有抗炎和抗肿瘤活性。
YYA-021
T6256
YYA-021具有高抗HIV 活性和低细胞毒性,是一种抑制HIV 进入的小分子CD4模拟物,。
Moringin
TN4583
Moringin 是一种异硫氰酸酯,由 Moringa oleifera 种子中存在的硫代葡萄糖苷前体 glucoMoringin 通过黑芥子酶介导水解获得。Moringin 具有抗炎和抗氧化特性。
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