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gp120/CD4

In molecular biology, CD4 (cluster of differentiation 4) is a glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). CD4 is found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells. Envelope glycoprotein GP120 (or gp120) is a glycoprotein exposed on the surface of the HIV envelope. The 120 in its name comes from its molecular weight of 120 kDa. Gp120 is essential for virus entry into cells as it plays a vital role in attachment to specific cell surface receptors. These receptors are DC-SIGN, Heparan Sulfate Proteoglycan and a specific interaction with the CD4 receptor, particularly on helper T-cells. Binding to CD4 induces the start of a cascade of conformational changes in gp120 and gp41 that lead to the fusion of the viral membrane with the host cell membrane. Binding to CD4 is mainly electrostatic although there are van der Waals interactions and hydrogen bonds.

Cat. No.	Product Name	CAS No.	Purity
T35388	Anti-mouse CD4-InVivo Anti-mouse CD4-InVivo		98%
T35388
TN4778	Physalin H 化合物 TN4778	70241-09-7	98%
TN4778	Physalin H is an Hh signaling inhibitor blocks GLI1-DNA-complex formation, it also strong quinone reductase induction activity with IR (Induction ratio, QR induc...
TN4130	Germacrone 4,5-epoxide 化合物 TN4130	92691-35-5	98%
TN4130	(4S,5S)-(+)-Germacrone-4,5-epoxide inhibits certain subtypes of cytochrome P450 (CYP).
T6418	BMS-378806 化合物BMS378806	357263-13-9	98%
T6418	BMS378806 是一种 HIV-1 抑制剂，可选择性抑制 HIV-1 gp120 结合到 CD4 受体，EC50为 0.85-26.5 nM。
TN1047	Ingenol mebutate 巨大戟醇甲基丁烯酸酯	75567-37-2	98%
TN1047	Ingenol mebutate 是 PKC 的有效激动剂，包括 PKC-α、PKC-β、PKC-γ、PKC-δ 和 PKC-ε，Kis 为 0.3、0.105、0.162、0.376 和 0.171 nM。 Ingenol mebutate 具有抗炎和抗肿瘤活性。
T6256	YYA-021 化合物YYA021	144217-65-2	98%
T6256	YYA021具有高抗HIV 活性和低细胞毒性，是一种抑制HIV 进入的小分子CD4模拟物,。
TN4583	Moringin 辣木籽素	73255-40-0	98%
TN4583	Moringin 是一种异硫氰酸酯，由 Moringa oleifera 种子中存在的硫代葡萄糖苷前体 glucoMoringin 通过黑芥子酶介导水解获得。Moringin 具有抗炎和抗氧化特性。