规格

价格

库存

数量

2 mg

¥ 251

现货

5 mg

¥ 417

现货

10 mg

¥ 583

现货

25 mg

¥ 987

现货

50 mg

¥ 1,480

现货

100 mg

¥ 2,220

现货

200 mg

¥ 3,330

现货

1 mL x 10 mM (in DMSO)

¥ 456

现货

生物活性

产品描述	Bepridil hydrochloride (CERM 1978) is a calcium channel blocker and also inhibits Na+/Ca2+ exchange (NCX), sodium channels and cardiac sarcolemmal KATP channels.
体外活性	Bepridil (1-100 microM) inhibited the K(ATP) channel current in a concentration-dependent manner. The IC(50) value of bepridil was estimated to be 10.5 microM for outward K(ATP) channel currents (holding potential, +60 mV) and 6.6 microM for inward K(ATP) channel currents (holding potential, -60 mV). Bepridil (0.1-30 microM) also inhibited K(Na) channel currents measured at the holding potential of -60 mV, in a concentration-dependent manner with an IC(50) value of 2.2 microM [2].
体内活性	The predominant effects of Bepridil (cumulative dose = 9.0 mg/kg i.v.) in the conscious rat were reduced coronary vascular resistance and heart rate. Bepridil showed selectivity for the coronary circulation since systemic vascular resistance was not significantly reduced until cumulative i.v. dosage of 21.0 mg/kg was administered [1].
别名	盐酸苄普地尔, CERM 1978

化学信息

分子量	403
分子式	C₂₄H₃₅ClN₂O
CAS No.	68099-86-5
Smiles	Cl.CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1
密度	1.054g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 130 mg/mL (322.58 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (9.93 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO