Tolfenamic Acid

Name: Tolfenamic Acid
Brand: TargetMol
SKU: T0784
Price: 326 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.97%

货号 T0784Cas号 13710-19-5

别名 托灭酸, 托芬那酸, Tolfedine, GEA 6414

Tolfenamic Acid (GEA 6414) 是一种非甾体抗炎剂和抗癌剂，可用于治疗偏头痛的症状。它能选择性地抑制COX-2的活性，在 LPS 诱导的犬 DH82 单核细胞/巨噬细胞中，对COX-2的IC50值为 13.49 μM(3.53 μg/mL)。

Tolfenamic Acid

一键复制产品信息

很棒

纯度: 99.97%

货号 T0784 别名 托灭酸, 托芬那酸, Tolfedine, GEA 6414Cas号 13710-19-5

规格	价格	库存	数量
500 mg	¥ 326	现货
1 mL x 10 mM (in DMSO)	¥ 395	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.97%

联系我们获取更多批次信息

资源下载:

COA HNMR HPLC 产品操作手册

产品介绍

Tolfenamic Acid AI Summary

Tolfenamic Acid exhibits a broad range of bioactivities, including significant antiviral, anti-inflammatory, and enzyme inhibitory properties. It demonstrates the ability to undergo in vitro ester hydrolysis in 80% human plasma at 37°C, with distinctly different half-lives for methyl ester (100.0 hours) and N,N-diethylglycolamide ester (0.08333 hours) hydrolysis. Additionally, the compound displays potent anti-inflammatory effects, reducing carrageenan-induced paw edema in rats by 24.0% at specific dosages. Tolfenamic Acid shows marked antiviral activity against JC polyomavirus and modest activity against SARS-CoV-2, although its efficacy for the latter is relatively weak with an inhibition IC50 greater than 19952.62 nM. It also exhibits inhibition of the CYP2C9 enzyme (Ki of 537650433122253.3 nM), COX-2 enzyme (IC50 of 1170.0 nM), and multiple cytochrome P450 enzymes. The compound has demonstrated hepatotoxic and ulcerogenic activities, evidenced by significant toxicity in rats at 760 uM/kg over four days, leading to a 50% mortality rate and substantial body weight reduction. Tolfenamic Acid inhibits various other enzymes and targets, such as SARS-CoV-2 protease, human AKR1C3 (Ki of 8.0 nM), and HDAC6. Its binding affinity to TTR is noted, with distinct IC50 and Kd values. The diverse bioactivities presented indicate potential therapeutic applications but also highlight significant toxicity that needs to be carefully evaluated..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Tolfenamic Acid (GEA 6414) is one of the class of non-steroidal anti-inflammatory drugs (NSAIDs). It is used to treat the symptoms of migraine.
靶点活性	COX-2:0.2 μM
别名	托灭酸, 托芬那酸, Tolfedine, GEA 6414

化学信息

分子量	261.70
分子式	C₁₄H₁₂ClNO₂
CAS No.	13710-19-5
Smiles	N(C1=C(C(O)=O)C=CC=C1)C2=C(C)C(Cl)=CC=C2
密度	1.2037 g/cm3 (Estimated)
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 49 mg/mL (187.24 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Corn Oil: 2 mg/mL (7.64 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8212 mL	19.1058 mL	38.2117 mL	191.0585 mL
5 mM	0.7642 mL	3.8212 mL	7.6423 mL	38.2117 mL
10 mM	0.3821 mL	1.9106 mL	3.8212 mL	19.1058 mL
20 mM	0.1911 mL	0.9553 mL	1.9106 mL	9.5529 mL
50 mM	0.0764 mL	0.3821 mL	0.7642 mL	3.8212 mL
100 mM	0.0382 mL	0.1911 mL	0.3821 mL	1.9106 mL