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AFN-1252
Synonyms: Debio 1452, API-1252货号 T4105Cas号 620175-39-5 一键复制产品信息纯度: 99.81%
很棒
很棒AFN-1252 (Debio 1452)是一种FabI 的高效抑制剂，能抑制金黄色葡萄球菌。
AFN-1252
一键复制产品信息 很棒纯度: 99.81%
货号 T4105Cas号 620175-39-5
别名 Debio 1452, API-1252
AFN-1252 (Debio 1452)是一种FabI 的高效抑制剂，能抑制金黄色葡萄球菌。
其他形式的 “AFN-1252”:
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 1 mg | ¥ 427 | 现货 | |
| 5 mg | ¥ 993 | 现货 | |
| 10 mg | ¥ 1,590 | 现货 | |
| 25 mg | ¥ 2,820 | 现货 | |
| 50 mg | ¥ 4,230 | 现货 | |
| 100 mg | ¥ 5,880 | 现货 | |
| 200 mg | ¥ 7,920 | 现货 | |
| 1 mL x 10 mM (in DMSO) | ¥ 819 | 现货 |
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产品介绍
AFN-1252 AI Summary
AFN-1252 demonstrates potent antibacterial activity, particularly against methicillin-susceptible and methicillin-resistant strains of Staphylococcus aureus and Staphylococcus epidermidis, with MIC50 values of <= 0.008 µg/mL. It also exhibits moderate antibacterial activity against Streptococcus pyogenes, Enterococcus faecium, and some strains of Escherichia coli and Klebsiella pneumoniae, with MIC values ranging from 0.5 to 4.0 µg/mL. However, the compound shows limited activity against Streptococcus pneumoniae and Stenotrophomonas maltophilia, with MIC values exceeding 4.0 µg/mL. The compound has a LogD7.4 value of 2.36 and a high plasma protein binding percentage of 94.56%, suggesting significant distribution in biological systems.
In terms of bioactivity, AFN-1252 effectively inhibits the Staphylococcus aureus FabI enzyme, with an IC50 value of 29.0 nM. It maintains metabolic stability in mouse liver microsomes and has acceptable pharmacokinetic parameters in Swiss albino CD-1 mice, including a half-life of 1.84 hours and an AUC of 2200.0 ng·hr/mL at an oral dose of 10 mg/kg. The compound is also highly protein-bound in mouse, rat, dog, and human serum, with a binding percentage of 95.0%.
Additionally, AFN-1252 exhibits antiviral properties, notably against SARS-CoV-2, by inhibiting virus-induced cytotoxicity in VERO-6 and Caco-2 cells and shows inhibition of the SARS-CoV-2 3CL-Pro protease. It presents a significant inhibitory effect (77.06%) on human HDAC6 using a commercial peptide substrate, although its inhibitory effect varies with different substrates.
Overall, AFN-1252 shows promise as a potent antibacterial and antiviral agent with substantial bioactivity against key bacterial enzymes and viral proteases..
Note: Summary generated by AI. Data source: ChEMBL 
生物活性
化学信息
储存&溶解度
| 产品描述 | AFN-1252 (Debio 1452)(Debio 1452) is an effective inhibitor of enoyl-acyl carrier protein reductase (FabI). It (≤0.12 μg/ml) inhibits all Clinicalal isolates of Staphylococcus aureus and Staphylococcus epidermidis. |
| 别名 | Debio 1452, API-1252 |
| 分子量 | 375.42 |
| 分子式 | C22H21N3O3 |
| CAS No. | 620175-39-5 |
| Smiles | CN(Cc1oc2ccccc2c1C)C(=O)\C=C\C1=CNC2=NC(=O)CCC2=C1 |
| 密度 | 1.28 g/cm3 (Predicted) |
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准 | ||||||||||||||||||||
| 溶解度信息 | DMSO: 5.8 mg/mL (15.45 mM), Sonication is recommended. | ||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||
DMSO
该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。 | |||||||||||||||||||||
计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
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