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Metoclopramide hydrochloride

Name: Metoclopramide hydrochloride
Brand: TargetMol
SKU: T1069
Price: 160 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 盐酸甲氧氯普胺, Metoclopramide HCl, Maxolon

货号 T1069Cas号 7232-21-5 一键复制产品信息纯度: 99.99%

很棒

Metoclopramide hydrochloride (Metoclopramide HCl) 是可口服的5-HT3和多巴胺D2受体拮抗剂，IC50值分别为 308 和 483 nM，用于恶心呕吐、胃食管反流和胃轻瘫的研究。

Metoclopramide hydrochloride

一键复制产品信息

很棒

纯度: 99.99%

货号 T1069Cas号 7232-21-5

别名 盐酸甲氧氯普胺, Metoclopramide HCl, Maxolon

Metoclopramide hydrochloride (Metoclopramide HCl) 是可口服的5-HT3和多巴胺D2受体拮抗剂，IC50值分别为 308 和 483 nM，用于恶心呕吐、胃食管反流和胃轻瘫的研究。

规格	价格	库存
10 mg	¥ 273	现货
25 mg	¥ 432	现货
50 mg	¥ 665	现货
100 mg	¥ 896	现货
200 mg	¥ 1,350	现货
500 mg	¥ 2,280	现货
1 mL x 10 mM (in DMSO)	¥ 160	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.99%

颜色: 白色

性状: Solid

资源下载: COA LCMS HNMR产品操作手册

产品介绍

Metoclopramide hydrochloride AI Summary

Metoclopramide hydrochloride exhibits a broad range of bioactivities across different assays and biological models. It demonstrates antiplasmodial activity against Plasmodium falciparum W2 with a pIC25 value of 4.9, measured using the SYBR green assay over 72 hours. The compound shows specific potency as a Rab9 Promoter Activator at 5623.4 nM and exhibits an IC50 greater than 50000.0 nM as an Estrogen Receptor-beta Coactivator Binding Inhibitor. Additionally, it acts as a differential inhibitor of the proliferation of Plasmodium falciparum line W2 at 15848.9 nM, and inhibits MPP8 Chromodomain interactions with Methylated Histone Tails at a potency of 89125.1 nM, and HP1-beta Chromodomain interactions at 10000.0 nM. Among its notable activities, it inhibits Histone Lysine Methyltransferase G9a at 22.4 nM and the ERG Ets/DNA interaction at 50118.7 nM. In cellular assays, Metoclopramide hydrochloride significantly inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells by 84.82% and 108.21% respectively at 10 µM. In a Wistar rat gastroparesis model, the compound improves gastric emptying by 41.0% at 10 mg/kg when administered intravenously post-meal, as measured after 15 minutes using a colorimetric method. Despite these activities, it shows very low efficacy in inhibiting cell viability in Vero E6 cells infected with SARS-CoV-2 (strain BavPat1), with an inhibition index of 0.02423 at a low MOI of 0.002 after 72 hours. Furthermore, Metoclopramide hydrochloride displays modest antifungal activity against Candida albicans (3.69% inhibition) and antibacterial activity against Klebsiella pneumoniae (10.19%), Pseudomonas aeruginosa (3.44%), Acinetobacter baumannii (16.26%), and Staphylococcus aureus MRSA (7.88%). However, it has negative inhibition rates against Cryptococcus neoformans (-1.39%) and Escherichia coli (-6.93%)..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Metoclopramide hydrochloride (Metoclopramide HCl) is a selective dopamine D2 receptor antagonist, used as an antiemetic.
靶点活性	5-HT3 receptor:308 nM (IC50), D2 receptor:483 nM (IC50)
别名	盐酸甲氧氯普胺, Metoclopramide HCl, Maxolon

化学信息

分子量	336.26
分子式	C₁₄H₂₂ClN₃O₂·HCl
CAS No.	7232-21-5
Smiles	Cl.CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

Ethanol: 62 mg/mL (184.38 mM), Sonication is recommended.

H2O: 61 mg/mL (181.41 mM), Sonication is recommended.

DMSO: 50 mg/mL (148.69 mM), Sonication is recommended.

溶液配制表

DMSO/H2O/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.9739 mL	14.8694 mL	29.7389 mL	148.6945 mL
5 mM	0.5948 mL	2.9739 mL	5.9478 mL	29.7389 mL
10 mM	0.2974 mL	1.4869 mL	2.9739 mL	14.8694 mL
20 mM	0.1487 mL	0.7435 mL	1.4869 mL	7.4347 mL
50 mM	0.0595 mL	0.2974 mL	0.5948 mL	2.9739 mL
100 mM	0.0297 mL	0.1487 mL	0.2974 mL	1.4869 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

vomiting Serotonin Receptor reflux nausea Metoclopramide hydrochloride Metoclopramide mAChR Inhibitor inhibit gastroparesis gastro-oesophageal DopamineReceptor Dopamine Receptor Dopamine 5-hydroxytryptamine Receptor 5HTReceptor 5-HT Receptor 5HT Receptor 5-HT

Metoclopramide hydrochloride

Metoclopramide hydrochloride