Terminolic acid

Name: Terminolic acid
Brand: TargetMol
SKU: TN6722
Price: 289 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.14%

货号 TN6722Cas号 564-13-6

别名 2α,6β,23-trihydroxyl oleanolic acid

Terminolic acid (2α,6β,23-trihydroxyl oleanolic acid) 是一种从 Combretum racemosum 中分离得到的五环三萜糖苷，可通过与 IL-1β 和 IL-6 的受体活性位点结合抑制促炎细胞因子，并通过与 IL-4 受体结合位点结合增强抗炎细胞因子。它还表现出适度的抗菌活性。

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Terminolic acid

一键复制产品信息

很棒

纯度: 99.14%

货号 TN6722 别名 2α,6β,23-trihydroxyl oleanolic acidCas号 564-13-6

规格	价格	库存
1 mg	¥ 289	现货
5 mg	¥ 663	现货
10 mg	¥ 968	现货
25 mg	¥ 1,620	现货
50 mg	¥ 2,380	现货
100 mg	¥ 3,580	现货
1 mL x 10 mM (in DMSO)	¥ 1,050	现货

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产品介绍

Terminolic acid AI Summary

Terminolic acid shows limited antifungal activities and enzyme inhibitory properties. It exhibits no significant activity in inhibiting Saccharomyces cerevisiae fatty acid synthase and demonstrates IC50 values higher than 50.0 µg/mL against Candida albicans ATCC 90028 and Cryptococcus neoformans ATCC 90113. However, it shows some antifungal activity against Candida albicans, with Minimum Inhibitory Concentration (MIC) values of 62.5 µg/mL for the ATCC 90028 strain and 125.0 µg/mL for both the clinical isolate and MTCC 1637 strain. Regarding enzyme inhibition, Terminolic acid inhibits alpha-glucosidase enzymes in Saccharomyces cerevisiae and rat intestines by 21.0% and 10.1%, respectively, and shows a 7.5% inhibition rate against pig pancreas alpha-amylase..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Terminolic acid (2α,6β,23-trihydroxyl oleanolic acid) is a pentacyclic triterpenoid glucoside isolated from Combretum racemosum, can inhibit the pro-inflammatory cytokines by binding to receptor active site of IL-1β and IL-6, and enhance anti-inflammatory cytokines by binding to IL-4 receptor binding sites. It also exhibits moderate antibacterial activity.
别名	2α,6β,23-trihydroxyl oleanolic acid

化学信息

分子量	504.7
分子式	C₃₀H₄₈O₆
CAS No.	564-13-6
Smiles	[H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]1(C)C2=CC[C@]2([H])[C@@]3(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@]3([H])[C@H](O)C[C@@]12C)C(O)=O
密度	1.23 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 45 mg/mL (89.16 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9814 mL	9.9069 mL	19.8138 mL	99.0688 mL
5 mM	0.3963 mL	1.9814 mL	3.9628 mL	19.8138 mL
10 mM	0.1981 mL	0.9907 mL	1.9814 mL	9.9069 mL
20 mM	0.0991 mL	0.4953 mL	0.9907 mL	4.9534 mL
50 mM	0.0396 mL	0.1981 mL	0.3963 mL	1.9814 mL