规格

价格

库存

数量

1 mg

¥ 449

现货

5 mg

¥ 1,080

现货

10 mg

¥ 1,930

现货

25 mg

¥ 3,290

现货

50 mg

¥ 4,780

现货

100 mg

¥ 6,830

现货

1 mL x 10 mM (in DMSO)

¥ 982

现货

生物活性

产品描述	IDO1/TDO-IN-4 is a novel dual inhibitor of IDO1/TDO with antidepressant activity, forming hydrogen bonds with IDO1 and π-π stacking interactions with TDO. IDO1/TDO-IN-4 rescues lipopolysaccharide-induced depressive-like behaviors in mice, used for cancer and Alzheimer's disease research.
靶点活性	IDO1:3.53 μM, TDO:1.15 μM
体外活性	IDO1/TDO-IN-4 对 IDO1 和 TDO 具有双重抑制作用， IC50 分别为 3.53 μM 和 1.15 μM。 IDO1/TDO-IN-4 ( 0-2 μM, 1 h) 能够抑制由 LPS 引起的 BV2 小胶质细胞的活性。[1]
体内活性	IDO1/TDO-IN-4（20 mg/kg）还挽救了脂多糖诱导的小鼠抑郁样行为。[1]

化学信息

分子量	234.26
分子式	C₁₄H₁₀N₄
CAS No.	461424-21-5
Smiles	N1=CNC(=C1)C=2N=CC=C3C4=CC=CC=C4NC23
颜色	White
物理性状	Solid

储存&溶解度

存储

store at low temperature,keep away from moisture | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 100 mg/mL (426.88 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2688 mL	21.3438 mL	42.6876 mL	213.4381 mL
5 mM	0.8538 mL	4.2688 mL	8.5375 mL	42.6876 mL
10 mM	0.4269 mL	2.1344 mL	4.2688 mL	21.3438 mL
20 mM	0.2134 mL	1.0672 mL	2.1344 mL	10.6719 mL
50 mM	0.0854 mL	0.4269 mL	0.8538 mL	4.2688 mL
100 mM	0.0427 mL	0.2134 mL	0.4269 mL	2.1344 mL