规格

价格

库存

数量

1 mg

¥ 329

现货

5 mg

¥ 787

现货

10 mg

¥ 1,230

现货

25 mg

¥ 1,980

现货

50 mg

¥ 3,730

现货

100 mg

¥ 5,320

现货

200 mg

¥ 7,280

现货

1 mL x 10 mM (in DMSO)

¥ 913

现货

生物活性

产品描述	Rapastinel Trifluoroacetate (GLYX-13 Trifluoroacetate) is an NMDA receptor modulator with glycine-site partial agonist properties.
体内活性	Rapastinel Trifluoroacetate, a tetrapeptide (Thr-Pro-Pro-Thr-amide), has been reported to have fast acting antidepressant properties in man based upon its N-methyl-D-aspartate receptor (NMDAR) glycine site functional partial agonism.
动物实验	C57BL/6J mice given a single dose or subchronic ketamine (30 mg/kg.i.p.) showed acute or persistent deficits in NOR, respectively.?Acute i.v. rapastinel (1.0 mg/kg), did not induce NOR deficit.?Pre-treatment with Rapastinel Trifluoroacetate?significantly prevented acute ketamine-induced NOR deficit.?Rapastinel Trifluoroacetate?(1.0 mg/kg, but not 0.3 mg/kg, iv) significantly reversed both subchronic ketamine- and subchronic PCP-induced NOR deficits.?Rapastinel Trifluoroacetate?also potentiated the atypical antipsychotic drug with antidepressant properties, lurasidone, to restore NOR in subchronic ketamine-treated mice.?Unlike ketamine,Rapastinel Trifluoroacetate?does not induce a declarative memory deficit in mice, and can prevent or reverse the ketamine-induced NOR deficit.?Further study is required to determine if these differences translate during clinical use of ketamine and rapastinel as fast acting antidepressant drugs and if rapastinel could have non-ionotropic effects as an add-on therapy with antipsychotic/antidepressant medications.
别名	Thr-Pro-Pro-Thr-NH2 Trifluoroacetate, GLYX-13 Trifluoroacetate

化学信息

分子量	527.49
分子式	C₂₀H₃₂F₃N₅O₈
CAS No.	1435786-04-1
Smiles	OC(=O)C(F)(F)F.C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(N)=O
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 125 mg/mL (236.97 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (7.58 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8958 mL	9.4789 mL	18.9577 mL	94.7885 mL
5 mM	0.3792 mL	1.8958 mL	3.7915 mL	18.9577 mL
10 mM	0.1896 mL	0.9479 mL	1.8958 mL	9.4789 mL
20 mM	0.0948 mL	0.4739 mL	0.9479 mL	4.7394 mL
50 mM	0.0379 mL	0.1896 mL	0.3792 mL	1.8958 mL
100 mM	0.0190 mL	0.0948 mL	0.1896 mL	0.9479 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

Rapastinel Trifluoroacetate

Rapastinel Trifluoroacetate

产品介绍

引用文献

计算器

体内实验配液计算器

剂量转换

关键词

Rapastinel Trifluoroacetate

Rapastinel Trifluoroacetate