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Tolperisone hydrochloride
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很棒纯度: 99.51%
货号 T0511Cas号 3644-61-9
别名 盐酸托哌酮, 托哌酮盐酸盐, Tolperisone HCl, Muscalm, Midocalm
Tolperisone hydrochloride (Muscalm) 是中枢作用肌肉松弛剂，可用于研究神经疾病引起的病理性横纹肌硬化(锥体束损伤、脊髓病、多发性硬化症、脑脊髓炎)、痉挛性麻痹及其他肌肉张力障碍相关的脑病。
其他形式的 “Tolperisone hydrochloride”:
Tolperisone hydrochloride
一键复制产品信息 很棒纯度: 99.51%
货号 T0511 别名 盐酸托哌酮, 托哌酮盐酸盐, Tolperisone HCl, Muscalm, MidocalmCas号 3644-61-9
Tolperisone hydrochloride (Muscalm) 是中枢作用肌肉松弛剂，可用于研究神经疾病引起的病理性横纹肌硬化(锥体束损伤、脊髓病、多发性硬化症、脑脊髓炎)、痉挛性麻痹及其他肌肉张力障碍相关的脑病。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 10 mg | ¥ 137 | 现货 | |
| 25 mg | ¥ 228 | 现货 | |
| 50 mg | ¥ 342 | 现货 | |
| 100 mg | ¥ 512 | 现货 | |
| 500 mg | ¥ 1,250 | 现货 | |
| 1 mL x 10 mM (in DMSO) | ¥ 99 | 现货 |
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产品介绍
Tolperisone hydrochloride AI Summary
Tolperisone hydrochloride exhibits a broad range of bioactivities across various assays. It has a potency of 12,589.3 nM in modulating Lamin A splicing and acts as an inhibitor with potencies of 5,623.4 nM against ALDH1A1 and 23,109.3 nM against human tyrosyl-DNA phosphodiesterase 1 (TDP1) in cells (absence of CPT). As an antimalarial agent, it shows a delayed death inhibition of the malarial parasite plastid with potencies of 13,459.1 nM at both 48-hour and 96-hour incubations. For gametocytocidal activity, its potency is 22,387.2 nM. In antiviral assays, it exhibits an AC50 of 707.9 nM (or 0.7079 µM) in blocking the entry of the Ebola Virus.
Furthermore, Tolperisone hydrochloride significantly inhibits sodium fluorescein uptake in OATP1B1 (96.3%) and OATP1B3 (112.68%) transfected CHO cells at 10 µM. It also inhibits cell viability in Vero E6 cells infected with SARS-CoV-2 at a low MOI of 0.002 after 72 hours, showing an inhibition index of 1.172. It reduces SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells at 10 µM after 48 hours with inhibition percentages of -8.48% and 0.1%, respectively. Lastly, it inhibits SARS-CoV-2 3CL-Pro protease activity by 31.1% at 20 µM..
Note: Summary generated by AI. Data source: ChEMBL 
生物活性
化学信息
储存&溶解度
| 产品描述 | Tolperisone hydrochloride (Muscalm), a centrally acting muscle relaxant, is used in the therapy of pathologically increased tone of the cross-striated muscle resulted by neurological diseases (damage of the encephalomyelitis, myelopathy, multiple sclerosis, pyramidal tract) and of spastic paralysis and other encephalopathies manifested with muscular dystonia. |
| 体内活性 | Tolperisone hydrochloride是一种安全有效的治疗疼痛反射性肌肉痉挛的药物,且没有中枢性肌肉松弛药的典型副作用。Tolperisone可以阻断蜗牛神经元的钙离子流,降低青蛙郎氏节处钠钾离子渗透性,并且对电流通过Nav1.6通道（异源表达）有抑制作用。 |
| 别名 | 盐酸托哌酮, 托哌酮盐酸盐, Tolperisone HCl, Muscalm, Midocalm |
| 分子量 | 281.82 |
| 分子式 | C16H24ClNO |
| CAS No. | 3644-61-9 |
| Smiles | Cl.CC(CN1CCCCC1)C(=O)C1=CC=C(C)C=C1 |
| 密度 | no data available |
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| 溶解度信息 | DMSO: 55 mg/mL (195.16 mM), Sonication is recommended.  Ethanol: 52 mg/mL (184.51 mM), Sonication is recommended. H2O: 51 mg/mL (180.97 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
| 体内实验配方 | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.1 mM), Sonication is recommended. 请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。 | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
H2O/Ethanol/DMSO
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计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， 一共给药动物10只，您使用的配方为5%
DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。 以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
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