Name: ML753286
Brand: TargetMol
SKU: T16113
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

25 mg

¥ 10,600

6-8周

50 mg

¥ 13,800

6-8周

100 mg

¥ 17,500

6-8周

生物活性

产品描述	ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions. ML753286 is an orally active and selective inhibitor of BCRP (IC50: 0.6 μM). It is also stable in plasma across species.
靶点活性	BCRP:0.6 μM
体外活性	ML753286 shows IC50 values of >30, 0.6, and 39.0 μM for the inhibition of P-gp-, BCRP-, and OATP mediated transport, respectively.
体内活性	ML753286 (25- or 50-mg/kg (PO); 10 or 20 mg/kg (IV); 0.083-24 hours) appears to fully suppress Bcrp functions in rats at 25 mg/kg p.o. or at 20 mg/kg i.v. In Bcrp KO rats, pre-administered ML753286(25-mg/kg ; WT rats) and pre-administered ML753286 (50-mg/kg; WT rats), the tmax values in plasma were 1.4, 4.0, and 4.1 hours , respectively.

化学信息

分子量	355.43
分子式	C₂₀H₂₅N₃O₃
CAS No.	1699720-89-2
Smiles	[H][C@]12Cc3c([nH]c4cc(OC)ccc34)[C@H](CC(C)C)N1C(=O)[C@H](C)NC2=O
密度	1.27 g/cm3 (Predicted)