Powder: -20°C for 3 years | In solvent: -80°C for 1 year
G43 是一种有效的选择性 glucosyltransferase 抑制剂,对 GtfB 和 GtfC 具有抑制作用,Kd 值分别为3.7 μM和46.9 nM。G43 在体内外具有抗变形链球菌 (S. mutans)活性,可用于研究龋齿。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,300 | 现货 | ||
5 mg | ¥ 2,920 | 现货 | ||
10 mg | ¥ 4,290 | 现货 | ||
25 mg | ¥ 6,890 | 现货 | ||
50 mg | ¥ 9,320 | 现货 | ||
100 mg | ¥ 12,500 | 现货 | ||
500 mg | ¥ 24,900 | 现货 |
产品描述 | G43 is a potent and selective glucosyltransferase inhibitor that inhibits GtfB and GtfC with Kd values of 3.7 μM and 46.9 nM, respectively.G43 exhibits in vitro and in vivo anti-Streptococcus mutans activity and can be used for caries studies. |
体外活性 |
G43 (16 h) inhibits Streptococcus mutans biofilm by 85% at a concentration of 12.5 μM.[1] G43 (25 μM; 24 h) reduces glucan production by glycosyltransferase (Gtfs) and continuously inhibits the activities of GtfB and GtfC, with an inhibition rate of 80% for both enzymes.[1] G43 (25 μM; 24 h) has no significant effect on the expression of gtfs (gtfB, gtfC and gtfD) in UA159 mutans Streptococcus mutans.[1] G43 (50 μM; 24-48 h) reduces biofilm formation by reducing the production of water-insoluble exopolysaccharides in wild-type Streptococcus mutans.[2] |
体内活性 | G43 (100 µM; administered topically twice daily for 4 weeks; rat with S. mutans UA159 infected) reduces Streptococcus mutans virulence but did not lose weight over the course of the study. in vivo.[1] |
别名 | G 43, G-43 |
分子量 | 341.34 |
分子式 | C16H11N3O4S |
CAS No. | 690693-02-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (131.83 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.9296 mL | 14.6482 mL | 29.2963 mL | 73.2408 mL |
5 mM | 0.5859 mL | 2.9296 mL | 5.8593 mL | 14.6482 mL | |
10 mM | 0.293 mL | 1.4648 mL | 2.9296 mL | 7.3241 mL | |
20 mM | 0.1465 mL | 0.7324 mL | 1.4648 mL | 3.662 mL | |
50 mM | 0.0586 mL | 0.293 mL | 0.5859 mL | 1.4648 mL | |
100 mM | 0.0293 mL | 0.1465 mL | 0.293 mL | 0.7324 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
G43 690693-02-8 Metabolism Microbiology/Virology Antibacterial Transferase G 43 G-43 Inhibitor inhibitor inhibit