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NAN-190 hydrobromide

Name: NAN-190 hydrobromide
Brand: TargetMol
SKU: T12172
Price: 153 CNY
Availability: InStock
Rating: 5 (10 reviews)

货号 T12172Cas号 115338-32-4 一键复制产品信息纯度: 95.20%

很棒

NAN-190 hydrobromide 是一种5-HT1A 选择性拮抗剂。

NAN-190 hydrobromide

一键复制产品信息

很棒

纯度: 95.20%

货号 T12172Cas号 115338-32-4

NAN-190 hydrobromide 是一种5-HT1A 选择性拮抗剂。

规格	价格	库存
5 mg	¥ 153	现货
10 mg	¥ 248	现货
25 mg	¥ 309	现货
50 mg	¥ 398	现货
100 mg	¥ 548	现货
1 mL x 10 mM (in DMSO)	¥ 198	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 95.20%

颜色: 白色

性状: Solid

资源下载: COA LCMS HNMR产品操作手册

产品介绍

NAN-190 hydrobromide AI Summary

NAN-190 hydrobromide exhibits antiplasmodial activity against multiple strains of Plasmodium falciparum, with IC50 values of 12589.25 nM, 6309.57 nM, and 3162.28 nM against strains 3D7, HB3, and W2 respectively, after 72 hours by SYBR green assay. Additionally, it demonstrates bioactivity by inhibiting the proliferation of Plasmodium falciparum and various human enzymes, including JMJD2E, APE1, ALDH1A1, and HPGD. This compound also modulates cellular functions such as histone modifications, protein interactions, and virus entry, with notable potency in the nanomolar range. Moreover, NAN-190 hydrobromide induces cell cycle arrest in human PC3 cells, leading to accumulations at G1, G2, and S phases at different time points, and shows moderate induction of apoptosis over 24, 48, and 72-hour periods. In antiviral assays, NAN-190 hydrobromide inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells and VERO-6 cells with inhibition rates of 17.7% and 0.31% respectively, at a concentration of 10 µM after 48 hours. It further shows a SARS-CoV-2 3CL-Pro protease inhibition rate of 16.44% at a concentration of 20 µM. These bioactivities suggest potential for continued investigation in drug development, targeting both parasitic and viral pathogens..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	NAN-190 hydrobromide is an antagonist of serotonin receptor 5-HT.

化学信息

分子量	474.39
分子式	C₂₃H₂₈BrN₃O₃
CAS No.	115338-32-4
Smiles	Br.COc1ccccc1N1CCN(CCCCN2C(=O)c3ccccc3C2=O)CC1
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 8.33 mg/mL (17.56 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.11 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1080 mL	10.5399 mL	21.0797 mL	105.3985 mL
5 mM	0.4216 mL	2.1080 mL	4.2159 mL	21.0797 mL
10 mM	0.2108 mL	1.0540 mL	2.1080 mL	10.5399 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。