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RU 24969 free base

Name: RU 24969 free base
Brand: TargetMol
SKU: T8593
Price: 552 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 97.38%

货号 T8593Cas号 66611-26-5

别名 5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole

RU 24969 (5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole) 是 5-HT1A 和 5-HT1B 受体的选择性激动剂，Ki 值分别为 0.38 和 2.5 nM。它可减少液体消耗并增加向前运动。

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RU 24969 free base

一键复制产品信息

很棒

纯度: 97.38%

货号 T8593 别名 5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoleCas号 66611-26-5

RU 24969 (5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole) 是 5-HT1A 和 5-HT1B 受体的选择性激动剂，Ki 值分别为 0.38 和 2.5 nM。它可减少液体消耗并增加向前运动。

规格	价格	库存
5 mg	¥ 552	现货
10 mg	¥ 827	现货
50 mg	¥ 2,667	现货
100 mg	¥ 3,987	现货
1 mL x 10 mM (in DMSO)	¥ 642	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 97.38%

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COA LCMS HNMR 产品操作手册

产品介绍

RU 24969 free base AI Summary

**RU 24969 free base** exhibits a broad spectrum of bioactivities, primarily related to serotonin receptor modulation and antiviral properties. It demonstrates high binding affinity towards various serotonin receptor subtypes, including 5-HT1, 5-HT1A, 5-HT1B, 5-HT2C, and 5-HT2, with Ki values in the nanomolar range. Specifically, it shows strong affinity for the 5-HT1A receptor (Ki ~10.9 nM), and varying inhibitory activity against different serotonin receptors with IC50 values such as 2.0 nM for 5-HT1B, 14.0 nM for 5-HT1A, and 5400.0 nM for 5-HT2. Additionally, it acts as a 5-HT6 receptor agonist with an IC50 of 79.0 nM and an EC50 of 200.0 nM for stimulating cAMP production. Beyond its role in neurotransmission, RU 24969 free base displays antiviral activity against SARS-CoV-2, inhibiting virus-induced cytotoxicity in Caco-2 and VERO-6 cells at micromolar concentrations. It also shows potential as a SARS-CoV-2 3CL-Pro protease inhibitor, with inhibition rates around 11-13% at 20µM. Furthermore, it inhibits human HDAC6 activity, though the inhibition effectiveness depends on the substrate used. These combined properties suggest that RU 24969 free base could be a valuable pharmacological agent for both neurological and antiviral applications..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	RU 24969 (5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole) is a selective agonist of 5-HT1A and 5-HT1B receptors.
靶点活性	5-HT1A receptor:2.5 nM (Ki), 5-HT1B receptor:0.38 nM (Ki)
别名	5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole

化学信息

分子量	228.29
分子式	C₁₄H₁₆N₂O
CAS No.	66611-26-5
Smiles	COC1=CC2=C(NC=C2C2=CCNCC2)C=C1
密度	1.174 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 30 mg/mL (131.41 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.76 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3804 mL	21.9020 mL	43.8039 mL	219.0197 mL
5 mM	0.8761 mL	4.3804 mL	8.7608 mL	43.8039 mL
10 mM	0.4380 mL	2.1902 mL	4.3804 mL	21.9020 mL
20 mM	0.2190 mL	1.0951 mL	2.1902 mL	10.9510 mL
50 mM	0.0876 mL	0.4380 mL	0.8761 mL	4.3804 mL
100 mM	0.0438 mL	0.2190 mL	0.4380 mL	2.1902 mL