BAY-091

Name: BAY-091
Brand: TargetMol
SKU: T60147
Price: 756 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.23%

货号 T60147Cas号 2922280-34-8

BAY-091 是一种新型高效和高选择性的 PIP4K2A 激酶抑制剂。

为众多的药物研发团队赋能，

让新药发现更简单！

BAY-091

一键复制产品信息

很棒

纯度: 99.23%

货号 T60147Cas号 2922280-34-8

BAY-091 是一种新型高效和高选择性的 PIP4K2A 激酶抑制剂。

规格	价格	库存
1 mg	¥ 756	现货
5 mg	¥ 1,870	现货
10 mg	¥ 2,750	现货
25 mg	¥ 4,390	现货
50 mg	¥ 5,920	现货
100 mg	¥ 7,980	现货
200 mg	¥ 10,700	现货
1 mL x 10 mM (in DMSO)	¥ 1,870	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.23%

联系我们获取更多批次信息

资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

BAY-091 AI Summary

BAY-091 exhibits selective bioactivity as an inhibitor of the PIP4K2A enzyme, with its potency varying across different cell types and assays. In sf21 cells, it strongly inhibits PIP4K2A activity with IC50 values ranging from 1.0 nM to 16.0 nM. However, in human THP-1 cells, its potency drops significantly, demonstrating an IC50 greater than 50,000 nM, and binding affinity with EC50 values of 1100.0 nM and 1800.0 nM in distinct assays. The compound also displays metabolic stability in rat and human liver microsomes and hepatocytes, and moderate permeability in Caco-2 cells and the PAMPA assay. Its impact on CYP enzymes is limited, and it does not exhibit significant antiproliferative activity against various cell lines. In terms of effects on different cell types, BAY-091 shows variability in growth rates: 0.67 to 0.98 in HEK293T cells, 0.1 to 0.91 in U2OS cells, and 0.65 to 0.93 in human fibroblast cells, hinting at its differential impact on cell viability and proliferation. Additionally, the compound affects the thermal stability of protein domains, generally decreasing the melting temperature (TM) of most domains, with a notable increase in TM observed in the domain spanning residues E122 to S403, which suggests potential stabilization in that region..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	BAY-091 is a novel potent and highly selective PIP4K2A kinase inhibitor.

化学信息

分子量	440.47
分子式	C₂₆H₂₁FN₄O₂
CAS No.	2922280-34-8
Smiles	N([C@@H](C(O)=O)CC)C=1C2=C(N=C(C1C#N)C3=CC=C(C=C3)C4=C(F)C(C)=CC=C4)C=NC=C2
密度	1.35 g/cm3 at 20℃ (Predicted)

储存&溶解度

存储

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 112.5 mg/mL (255.41 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2703 mL	11.3515 mL	22.7030 mL	113.5151 mL
5 mM	0.4541 mL	2.2703 mL	4.5406 mL	22.7030 mL
10 mM	0.2270 mL	1.1352 mL	2.2703 mL	11.3515 mL
20 mM	0.1135 mL	0.5676 mL	1.1352 mL	5.6758 mL
50 mM	0.0454 mL	0.2270 mL	0.4541 mL	2.2703 mL
100 mM	0.0227 mL	0.1135 mL	0.2270 mL	1.1352 mL