ZL006 growth inhibition of BCECs is not found at a low concentration of 0.001, 0.01, 0.1, 1, and 10 μg/mL. The cytotoxicity of T7-P-LPs/ZL006 is obviously enhanced at the concentration of 10 μg/mL. Cellular uptake of ZL006 loads P-LPs and T7-P-LPs after incubation for 0.5 h at the concentrations range from 100 μg/mL to 600 μg/mL in BCECs [1][2].

T7-P-LPs/ZL006 displays a significant enhance in drug accumulation in the brain tissue due to its better brain targeting delivery compared with P-LPs/ZL006 and free ZL006. P-LPs/ZL006 and T7-P-LPs/ZL006 show a significant decrease in drug accumulation in the liver and kidney compared with free ZL006 [1].