Name: Thioquinapiperifil dihydrochloride
Brand: TargetMol
SKU: T9773
Price: 517 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 517

现货

5 mg

¥ 1,320

现货

10 mg

¥ 1,910

现货

25 mg

¥ 2,890

现货

50 mg

¥ 3,970

现货

100 mg

¥ 5,370

现货

200 mg

¥ 6,900

现货

1 mL x 10 mM (in DMSO)

¥ 1,500

现货

产品介绍

生物活性

产品描述	Thioquinapiperifil dihydrochloride is a phosphodiesterase (PDE-5) inhibitor (IC50: 0.074 nM) that is potent, selective and non-competitive for investigational maturation.
靶点活性	PDE5:0.074 nM, PDE3:38 nM, PDE1:380 nM, PDE2:670 nM, PDE4:800 nM
体外活性	Thioquinapiperifil dihydrochloride (KF31327) (0.1-10 μM) inhibits platelet aggregation in a concentration-dependent manner. In the absence of nitroglycerin, higher concentrations of 1 and 10 μM of KF31327 are inhibits platelet aggregation in a concentration-dependent manner.[2] Thioquinapiperifil dihydrochloride (KF31327) shows a significant increase in cyclic GMP at 10 μM. After 5 min incubation, the mean cyclic GMP levels of KF31327-treated cells is 0.95±0.17 pmol/10 8 cells.[2]
别名	KF-31327

化学信息

分子量	485.05
分子式	C₂₄H₂₉ClN₆OS
CAS No.	204077-66-7
Smiles	Cl.Cl.CCn1c2cc3ncnc(NCc4ccccc4N4CCC(CO)CC4)c3cc2[nH]c1=S
颜色	Yellow
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 112.5 mg/mL (231.93 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.25 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0616 mL	10.3082 mL	20.6164 mL	103.0822 mL
5 mM	0.4123 mL	2.0616 mL	4.1233 mL	20.6164 mL
10 mM	0.2062 mL	1.0308 mL	2.0616 mL	10.3082 mL
20 mM	0.1031 mL	0.5154 mL	1.0308 mL	5.1541 mL
50 mM	0.0412 mL	0.2062 mL	0.4123 mL	2.0616 mL
100 mM	0.0206 mL	0.1031 mL	0.2062 mL	1.0308 mL

体内实验配液计算器