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AZD-7648

Name: AZD-7648
Brand: TargetMol
SKU: T7122
Price: 256 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.85%

货号 T7122Cas号 2230820-11-6

AZD-7648 是一种 DNA 依赖性蛋白激酶 (DNA-PK) 抑制剂，在酶试验中 IC50 为 0.63 nM，具有抗肿瘤活性。

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AZD-7648

一键复制产品信息

很棒

纯度: 99.85%

货号 T7122Cas号 2230820-11-6

AZD-7648 是一种 DNA 依赖性蛋白激酶 (DNA-PK) 抑制剂，在酶试验中 IC50 为 0.63 nM，具有抗肿瘤活性。

规格	价格	库存
1 mg	¥ 256	现货
5 mg	¥ 598	现货
10 mg	¥ 823	现货
25 mg	¥ 1,630	现货
50 mg	¥ 2,400	现货
100 mg	¥ 3,580	现货
1 mL x 10 mM (in DMSO)	¥ 553	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.85%

颜色: 白色

性状: Solid

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COA HPLC HNMR 产品操作手册

产品介绍

AZD-7648 AI Summary

AZD-7648 exhibits potent bioactivity as a DNA-PK inhibitor, with an IC50 of 0.6-0.631 nM in TR-FRET assays involving the DNA-PK catalytic subunit in human HeLa cells. It also effectively inhibits DNA-PK in human A549 cells with an IC50 range of 91.0-100.0 nM, showing a selective preference over other kinases such as PI3K isoforms, ATM, ATR, and mTOR. The compound has favorable oral bioavailability in Han Wistar rats and Beagle dogs and demonstrates adequate solubility in simulated intestinal and gastric fluids. Additionally, it shows moderate to high plasma protein binding, and metabolic stability in human liver microsomes with an intrinsic clearance of 6.4 mL.min-1.g-1. AZD-7648 induces apoptosis in human HCT-116 cells, disrupts mitochondrial function, causes cell cycle arrest, and shows synergistic antiproliferative and antitumor activity in animal models. While demonstrating minimal effects on hERG expressed in CHO cells, the compound exhibits complex impacts on the thermal stability of various protein domains. Overall, AZD-7648's bioactivity and pharmacokinetic profiles suggest significant potential for further evaluation as a targeted DNA-PK inhibitor..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.
靶点活性	DNA-PK:0.63 nM, ATM:17.93 μM, PI3Kγ:1.37 μM

化学信息

分子量	380.4
分子式	C₁₈H₂₀N₈O₂
CAS No.	2230820-11-6
Smiles	Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n(C3CCOCC3)c2n1
密度	1.60 g/cm3 (Predicted)

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 9.52 mg/mL (25.03 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6288 mL	13.1441 mL	26.2881 mL	131.4406 mL
5 mM	0.5258 mL	2.6288 mL	5.2576 mL	26.2881 mL
10 mM	0.2629 mL	1.3144 mL	2.6288 mL	13.1441 mL
20 mM	0.1314 mL	0.6572 mL	1.3144 mL	6.5720 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。