BRM/BRG1 ATP Inhibitor-1

Name: BRM/BRG1 ATP Inhibitor-1
Brand: TargetMol
SKU: T10616
Price: 1650 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.84%

货号 T10616Cas号 2270879-17-7

BRM/BRG1 ATP Inhibitor-1 是变构双 Brahma 同源物 (BRM)/SWI/SNF 相关的基质相关肌动蛋白依赖性调节剂，染色质亚家族 A 成员 2 和 BRG1/SMARCA4 ATP 酶活性抑制剂，IC50值低于 0.005 μM。

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BRM/BRG1 ATP Inhibitor-1

一键复制产品信息

很棒

纯度: 99.84%

货号 T10616Cas号 2270879-17-7

规格	价格	库存
1 mg	¥ 1,650	现货
5 mg	¥ 2,980	现货
10 mg	¥ 3,880	现货
25 mg	¥ 6,130	现货
50 mg	¥ 8,280	现货
100 mg	¥ 10,900	现货
1 mL x 10 mM (in DMSO)	¥ 2,320	现货

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产品介绍

BRM/BRG1 ATP Inhibitor-1 AI Summary

BRM/BRG1 ATP Inhibitor-1 exhibits multiple bioactivities, including significant inhibition of BRM/BRG1 mutants in human cells, leading to reduced KRT80 gene expression in vivo. It demonstrates potent anti-tumor activity in human cells xenografted in athymic nude mice, effectively inhibiting tumor growth at various dosages. The compound reaches the required unbound plasma concentration within a specific timeframe to mediate gene expression reduction. In luciferase reporter gene assays, BRM/BRG1 ATP Inhibitor-1 shows an EC50 value indicative of its efficacy in inhibiting BRM/BRG1 mutants. Additionally, it possesses noteworthy thermodynamic solubility at a defined pH. The compound also inhibits human cell proliferation, reflected in cell growth suppression, and demonstrates inhibitory effects on BRM/BRG1 mutant-dependent cell proliferation across different cell types, with varied EC50 values. Furthermore, BRM/BRG1 ATP Inhibitor-1 has been found to inhibit recombinant ATPases expressed in insect sf9 cells, with distinct IC50 values, illustrating its broad scope of bioactivity..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	BRM/BRG1 ATP Inhibitor-1 is an allosteric dual Brahma homolog (BRM)/SWI/SNF related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SMARCA2) and BRG1/SMARCA4 ATPase activity inhibitor (IC50s<0.005 μM).
靶点活性	BRM/BRG1:﹤0.005 µM

化学信息

分子量	318.27
分子式	C₁₁H₉F₃N₄O₂S
CAS No.	2270879-17-7
Smiles	OCc1cnc(F)cc1NC(=O)Nc1cc(ns1)C(F)F
密度	1.659 g/cm3 (Predicted)
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 145 mg/mL (455.59 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (15.71 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1420 mL	15.7099 mL	31.4199 mL	157.0993 mL
5 mM	0.6284 mL	3.1420 mL	6.2840 mL	31.4199 mL
10 mM	0.3142 mL	1.5710 mL	3.1420 mL	15.7099 mL
20 mM	0.1571 mL	0.7855 mL	1.5710 mL	7.8550 mL
50 mM	0.0628 mL	0.3142 mL	0.6284 mL	3.1420 mL
100 mM	0.0314 mL	0.1571 mL	0.3142 mL	1.5710 mL