Name: Iclepertin
Brand: TargetMol
SKU: T37089
Price: 461 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 461

现货

2 mg

¥ 673

现货

5 mg

¥ 1,120

现货

10 mg

¥ 1,650

现货

25 mg

¥ 2,470

现货

50 mg

¥ 3,520

现货

100 mg

¥ 4,770

现货

200 mg

¥ 6,420

现货

1 mL x 10 mM (in DMSO)

¥ 1,290

现货

产品介绍

生物活性

产品描述	Iclepertin (BI-425809) is an orally active and selective inhibitor of glycine transporter protein 1 (GlyT1).Iclepertin is used for the treatment of central nervous system disorders such as Alzheimer;s disease. Iclepertin is used for central nervous system disorders such as Alzheimer;s disease, schizophrenia and cognitive disorders.
靶点活性	GLT1:5.2 mM (rat primary neurons), GLT1:5 nM (human SK-N-MC cells)
体外活性	Iclepertin 作为 GlyT1 的抑制剂，其在大鼠原代神经元和人 SK-N-MC 细胞中的 IC50 值分别为 5.2 nM和 5.0 nM[1]。
体内活性	在大鼠中口服 Iclepertin(BI 425809)诱导甘氨酸脑脊液水平从30%（0.2 mg/kg）到 78%（2 mg/kg）的剂量依赖性增加[1]。
别名	BI-425809

化学信息

分子量	512.42
分子式	C₂₀H₁₈F₆N₂O₅S
CAS No.	1421936-85-7
Smiles	[H][C@@]12C[C@@]1(CN(C2)C(=O)c1cc(ccc1O[C@H](C)C(F)(F)F)S(C)(=O)=O)c1cc(on1)C(F)(F)F
密度	1.508 g/cm3 (Predicted)