Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Iclepertin (BI-425809) is a highly effective, selective, and orally bioavailable inhibitor of glycine transporter 1 (GlyT1). It exhibits no activity against GlyT2. Consequently, Iclepertin holds promise for advancing research on Alzheimer's disease and schizophrenia [1].
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 2,250 | 现货 | ||
5 mg | ¥ 5,630 | 现货 | ||
10 mg | ¥ 7,630 | 现货 | ||
25 mg | ¥ 11,300 | 现货 | ||
50 mg | ¥ 15,300 | 现货 |
产品描述 | Iclepertin (BI-425809) is a highly effective, selective, and orally bioavailable inhibitor of glycine transporter 1 (GlyT1). It exhibits no activity against GlyT2. Consequently, Iclepertin holds promise for advancing research on Alzheimer's disease and schizophrenia [1]. |
靶点活性 | GLT1:5 nM (IC50, In human SK-N-MC cells), GLT1:5.2 mM (IC50, In rat primary neurons) |
体外活性 | Iclepertin inhibits GlyT1 with the IC50 values of 5.2 nM in rat primary neurons and 5.0 nM in human SK-N-MC cells[1]. |
体内活性 | Single oral administration of Iclepertin induced a dose-dependent increase of glycine cerebrospinal fluid (CSF) levels. Oral administration of Iclepertin in rats induced a dose‐dependent increase of glycine CSF levels from 30% (0.2 mg/kg, not significant) to 78% (2 mg/kg), relative to vehicle[1]. |
分子量 | 512.42 |
分子式 | C20H18F6N2O5S |
CAS No. | 1421936-85-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Iclepertin 1421936-85-7 Inhibitor inhibitor inhibit