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YM976

Name: YM976
Brand: TargetMol
SKU: T7954
Price: 123 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.84%

货号 T7954Cas号 191219-80-4

YM976 是磷酸二酯酶 4 抑制剂(IC50:2.2 nM)。它能够抑制抗原诱导的气道反应，并有抗炎的作用。

为众多的药物研发团队赋能，

让新药发现更简单！

YM976

一键复制产品信息

很棒

纯度: 99.84%

货号 T7954Cas号 191219-80-4

YM976 是磷酸二酯酶 4 抑制剂(IC50:2.2 nM)。它能够抑制抗原诱导的气道反应，并有抗炎的作用。

规格	价格	库存
1 mg	¥ 123	现货
5 mg	¥ 273	现货
10 mg	¥ 437	现货
25 mg	¥ 732	现货
50 mg	¥ 1,070	现货
1 mL x 10 mM (in DMSO)	¥ 297	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.84%

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资源下载:

COA HNMR HPLC 产品操作手册

产品介绍

YM976 AI Summary

YM976 demonstrates diverse bioactivities across various biological targets and mechanisms. It acts as a potent inhibitor for enzymes such as HSD17B4, JMJD2E, ALDH1A1, Cytochrome P450 3A4, Cytochrome P450 2C9, and T. brucei phosphofructokinase, as well as for pathways including Anthrax Lethal Toxin Internalization, ROR gamma transcriptional activity, Lassa Virus entry into cells, and USP1/UAF1 complex. Additionally, it serves as an agonist for the Thyroid Stimulating Hormone Receptor and modulates lipid storage. It also inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) and G Protein Signaling RGS4 and acts as a substrate for Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1). Moreover, YM976 enhances Arylsulfatase A (ASA1) activity in the LOPAC Validation Assay and induces the Endoplasmic Reticulum Stress Response (ERSR) in human glioma cells. Specifically, YM976 exhibits antiviral properties by inhibiting SARS-CoV-2 induced cytotoxicity. It reduces cytotoxicity in Caco-2 cells by 6.16% at a concentration of 10 µM after 48 hours and shows an inhibition rate of 0.53% in VERO-6 cells under similar conditions. However, it appears to have a complex interaction with SARS-CoV-2 3CL-Pro protease, showing a negative inhibition percentage of -2.058% at 20 µM. Additionally, YM976 inhibits human HDAC6, with a slightly higher inhibition rate when using a commercial peptide substrate (17.75%) compared to a custom peptide substrate (-4.64%). Thus, YM976 holds potential as a multi-target therapeutic agent with antiviral and enzymatic regulatory activities..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	YM976 is an orally active PDE4 inhibitor (IC50:2.2 nM)
靶点活性	PDE4:2.2 nM

化学信息

分子量	313.78
分子式	C₁₇H₁₆ClN₃O
CAS No.	191219-80-4
Smiles	CCc1ccc2c(nc(=O)n(CC)c2n1)-c1cccc(Cl)c1
密度	1.27g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 3.14 mg/mL (10.01 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1869 mL	15.9347 mL	31.8695 mL	159.3473 mL
5 mM	0.6374 mL	3.1869 mL	6.3739 mL	31.8695 mL
10 mM	0.3187 mL	1.5935 mL	3.1869 mL	15.9347 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。