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Cefotetan

Name: Cefotetan
Brand: TargetMol
SKU: T7043
Price: 157 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.38%

货号 T7043Cas号 69712-56-7

别名 头孢替坦, Apacef

Cefotetan (Apacef) 是一种半合成的头霉素抗生素，能抑制细胞壁合成发挥杀菌作用。

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Cefotetan

一键复制产品信息

很棒

纯度: 99.38%

货号 T7043 别名 头孢替坦, ApacefCas号 69712-56-7

Cefotetan (Apacef) 是一种半合成的头霉素抗生素，能抑制细胞壁合成发挥杀菌作用。

规格	价格	库存
1 mg	¥ 157	现货
5 mg	¥ 339	现货
10 mg	¥ 512	现货
25 mg	¥ 817	现货
50 mg	¥ 1,260	现货
100 mg	¥ 1,890	现货
200 mg	¥ 2,790	现货
1 mL x 10 mM (in DMSO)	¥ 432	现货

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纯度: 98.87%

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COA HNMR LCMS 产品操作手册

产品介绍

Cefotetan AI Summary

Cefotetan exhibits a wide range of biological activities, including potent antibacterial and antiviral properties. Its antimicrobial effects include high potency against aerobic bacteria such as Escherichia coli and Klebsiella pneumoniae with minimum inhibitory concentrations (MIC) as low as 0.031 ug/mL. It is effective against anaerobic bacteria like Clostridium perfringens and Bacteroides thetaiotaomicron with MIC values ranging from 1.0 to 16.0 ug/mL, though it shows limited activity against others such as Bacteroides melaninogenicus with MIC values greater than 128.0 ug/mL. Additionally, Cefotetan has shown efficacy in inhibiting resistant strains of Escherichia coli and Shigella sonnei expressing beta-lactamase enzymes, with MIC values as low as 0.5 ug/mL. In pharmacokinetic studies, Cefotetan demonstrates species-specific distribution and clearance rates. In humans, it has a low volume of distribution (0.13 L.kg-1) and a short half-life of 4.5 hours, indicating moderate bioavailability and fast elimination. In animal models such as rats, dogs, and monkeys, the compound shows higher distribution volumes and faster clearance rates, suggesting variable bioavailability across species. Cefotetan also exhibits moderate hepatotoxicity with elevated levels of liver enzymes (ALT, AST, and alkaline phosphatase), albeit without severe liver damage. It also shows inhibitory activity on human bile salt export pump (BSEP) and multidrug resistance-associated proteins (MRP) with relatively low potency (IC50 values greater than 135,000 nM). In antiviral studies, Cefotetan demonstrates activity against SARS-CoV-2 by inhibiting the 3CL-Pro protease and decreasing viral-induced cytotoxicity in cell lines. However, its potency appears to be relatively low, with an IC50 value greater than 20,000 nM. Overall, Cefotetan is a multifaceted compound with notable antibacterial and antiviral activities, moderate hepatotoxicity, and specific pharmacokinetic profiles across different species..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Cefotetan (Apacef) Sodium (ICI-156834, YM-09330) is a second-generation cephalosporin, cephamycin antibiotic that is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative bacteria. Cefotetan binds to penicillin-binding proteins and disrupts the cell wall synthesis.
别名	头孢替坦, Apacef

化学信息

分子量	575.62
分子式	C₁₇H₁₇N₇O₈S₄
CAS No.	69712-56-7
Smiles	CO[C@]1(NC(=O)C2SC(S2)=C(C(N)=O)C(O)=O)[C@H]2SCC(CSc3nnnn3C)=C(N2C1=O)C(O)=O
密度	2.07 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 13 mg/mL (22.58 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (1.74 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7373 mL	8.6863 mL	17.3726 mL	86.8629 mL
5 mM	0.3475 mL	1.7373 mL	3.4745 mL	17.3726 mL
10 mM	0.1737 mL	0.8686 mL	1.7373 mL	8.6863 mL
20 mM	0.0869 mL	0.4343 mL	0.8686 mL	4.3431 mL