KCNQ1 activator-1

Name: KCNQ1 activator-1
Brand: TargetMol
SKU: T9778
Price: 348 CNY
Availability: InStock
Rating: 5 (10 reviews)

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纯度: 99.71%

货号 T9778Cas号 1008671-38-2

KCNQ1 activator-1 是有效的 KCNQ1通道激活剂。它在研究长 QT 综合征中有研究的价值。

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KCNQ1 activator-1

一键复制产品信息

很棒

纯度: 99.71%

货号 T9778Cas号 1008671-38-2

KCNQ1 activator-1 是有效的 KCNQ1通道激活剂。它在研究长 QT 综合征中有研究的价值。

规格	价格	库存
1 mg	¥ 348	现货
5 mg	¥ 861	现货
10 mg	¥ 1,380	现货
25 mg	¥ 2,430	现货
50 mg	¥ 3,480	现货
100 mg	¥ 4,810	现货
200 mg	¥ 6,490	现货
1 mL x 10 mM (in DMSO)	¥ 1,020	现货

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产品介绍

KCNQ1 activator-1 AI Summary

KCNQ1 activator-1 demonstrates a wide range of bioactivities across various assays. It is known to modulate splicing and enhance SMN2 splice variant expression. Additionally, it inhibits tau fibril formation, influences lipid storage modulators, targets the Menin-MLL interaction in leukemias, and inhibits the malaria parasite's plastid function. The compound also interacts with Marburg and Lassa viruses, induces DNA re-replication, and inhibits both the Hepatitis C Virus and GLP-1 receptor. It acts on Pin1 and provides integrin-mediated alleviation for muscular dystrophy. Moreover, it serves as an inhibitor of TDP-1, TDP-43, and PTHR, and functions as a stage-specific inhibitor of Vaccinia Orthopoxvirus. Notably, KCNQ1 activator-1 activates the Kv7.1 channel expressed in CHO cells, leading to depolarization-induced thallium influx within 3 minutes, as determined by patch clamp assay. It has an EC50 of 1690.0 nM and shows a relative activation of 285.0% compared to the control in the same assay, highlighting its effectiveness in modulating the Kv7.1 channel..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	2-Piperidinecarboxamide, N-[4-(4-methoxyphenyl)-2-thiazolyl]-1-(phenylsulfonyl)- is a potent KCNQ1 channel activator that can be used in long QT syndrome (LQTS) studies.

化学信息

分子量	457.57
分子式	C₂₂H₂₃N₃O₄S₂
CAS No.	1008671-38-2
Smiles	COc1ccc(cc1)-c1csc(NC(=O)C2CCCCN2S(=O)(=O)c2ccccc2)n1

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 250 mg/mL (546.36 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Corn Oil: 3.3 mg/mL (7.21 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1855 mL	10.9273 mL	21.8546 mL	109.2729 mL
5 mM	0.4371 mL	2.1855 mL	4.3709 mL	21.8546 mL
10 mM	0.2185 mL	1.0927 mL	2.1855 mL	10.9273 mL
20 mM	0.1093 mL	0.5464 mL	1.0927 mL	5.4636 mL
50 mM	0.0437 mL	0.2185 mL	0.4371 mL	2.1855 mL
100 mM	0.0219 mL	0.1093 mL	0.2185 mL	1.0927 mL