规格

价格

库存

数量

1 mg

¥ 313

现货

5 mg

¥ 828

现货

10 mg

¥ 1,230

现货

25 mg

¥ 1,980

现货

50 mg

¥ 3,730

现货

100 mg

¥ 5,360

现货

1 mL x 10 mM (in DMSO)

¥ 923

现货

生物活性

产品描述	Adavivint (SM04690) is a selective inhibitor of the typical Wnt signaling pathway. In SW480 cells, EC50=19.5 nM was measured using high-throughput TCF/LEF reporter gene experiments.
靶点活性	Wnt (SW480 cells):19.5 nM (EC50)
体内活性	Adavivint（SM04690）是一种新型Wnt通路抑制剂，用于治疗中度至重度膝部骨关节炎。
动物实验	A high-throughput screen was performed using a cell-based reporter assay for Wnt pathway activity to develop a small molecule designated SM04690. Its properties were evaluated in bone-marrow-derived human mesenchymal stem cells (hMSCs) to assess chondrocyte differentiation and effects on cartilage catabolism by immunocytochemistry and gene expression, and glycosaminoglycan breakdown. In vivo effects of SM04690 on Wnt signaling, cartilage regeneration and protection were measured using biochemical and histopathological techniques in a rodent acute cruciate ligament tear and partial medial meniscectomy (ACLT + pMMx) OA model.
别名	Adavivint (SM04690)

化学信息

分子量	505.55
分子式	C₂₉H₂₄FN₇O
CAS No.	1467093-03-3
Smiles	CC(C)CC(=O)Nc1cncc(c1)-c1ccc2[nH]nc(-c3nc4cncc(-c5cccc(F)c5)c4[nH]3)c2c1
密度	1.365 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 16.25 mg/mL (32.14 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.96 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO