规格

价格

库存

数量

1 mg

¥ 196

现货

5 mg

¥ 455

现货

10 mg

¥ 747

现货

25 mg

¥ 1,580

现货

50 mg

¥ 2,660

现货

100 mg

¥ 4,000

现货

生物活性

产品描述	VLX600 is an iron-chelating oxidative phosphorylation (OXPHOS) inhibitor, is a cell-permeable anticancer agent. It acts by reducing mitochondrial oxidative phosphorylation in tumor cells.
体外活性	VLX600 as a drug that is preferentially active against quiescent cells in colon cancer 3-D microtissues.?The anticancer activity is associated with reduced mitochondrial respiration, leading to bioenergetic catastrophe and tumour cell death.?VLX600 shows enhanced cytotoxic activity under conditions of nutrient starvation.?Importantly, VLX600 displays tumour growth inhibition in vivo.
细胞实验	HCT116, HT29, SW620, HT8, DLD and RKO cells.Concentration,0.1, 1, 10, 100μM. 72 hours

化学信息

分子量	317.35
分子式	C₁₇H₁₅N₇
CAS No.	327031-55-0
Smiles	CC(=NNc1nnc2c(n1)[nH]c1c(C)cccc21)c1ccccn1
密度	1.42 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 8 mg/mL (25.21 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Corn Oil: 0.5 mg/mL (1.58 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO