Imipramine hydrochloride

Name: Imipramine hydrochloride
Brand: TargetMol
SKU: T7941
Price: 198 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.98%

货号 T7941Cas号 113-52-0

别名 盐酸丙米嗪, 盐酸丙咪嗪, Tofranil, Melipramine, Imipramine HCl, Imipramine (hydrochloride), G 22355

Imipramine hydrochloride (Imipramine HCl) 可抑制血清素转运蛋白，IC50=32 nM。它可阻止胰酶的易位，阻碍 MV 和外泌体的分泌。

Imipramine hydrochloride

一键复制产品信息

很棒

纯度: 99.98%

货号 T7941 别名 盐酸丙米嗪, 盐酸丙咪嗪, Tofranil, Melipramine, Imipramine HCl, Imipramine (hydrochloride), G 22355Cas号 113-52-0

Imipramine hydrochloride (Imipramine HCl) 可抑制血清素转运蛋白，IC50=32 nM。它可阻止胰酶的易位，阻碍 MV 和外泌体的分泌。

规格	价格	库存
25 mg	¥ 198	现货
50 mg	¥ 289	现货
100 mg	¥ 413	现货
500 mg	¥ 986	5日内发货
1 mL x 10 mM (in DMSO)	¥ 455	现货

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产品介绍

Imipramine hydrochloride AI Summary

Imipramine hydrochloride exhibits a multifaceted bioactivity profile. It shows significant antidepressant effects in various behavioral assays in mice, such as inhibiting tetrabenazine-induced depression of motor activity (ED50 = 0.58 mg/kg) and ptosis (ED50 = 0.98 mg/kg), and reducing immobility time in the forced swim test. The compound also inhibits the norepinephrine transporter with a Ki of 12.0 nM and demonstrates modest activity against serotonin uptake (Ki = 41.8 nM). In pharmacokinetic studies, Imipramine hydrochloride shows high protein binding affinity and consistent distribution ratios across species. It exhibits a bioavailability of 42.0%, a clearance rate of 13.0 mL/min/kg, and a half-life of 16.0 hours in humans. The compound's metabolism results in glucuronide concentrations in bile and urine, indicating substantial metabolic processing. Additionally, Imipramine hydrochloride exhibits antiplasmodial activity against various strains of Plasmodium falciparum, with IC50 values ranging from 1258.93 nM to 15848.93 nM. It also demonstrates antiviral properties, albeit with modest efficacy in inhibiting SARS-CoV-2-induced cytotoxicity in Caco-2 cells and inhibiting the SARS-CoV-2 3CL-Pro protease by 30.25% at 20µM. The compound also exhibits modest antifungal and antibacterial activities, with specific but low inhibition rates against Candida albicans, Cryptococcus neoformans, and different bacterial strains including Klebsiella pneumoniae and Staphylococcus aureus MRSA. Furthermore, Imipramine hydrochloride influences various cell types differently, inhibiting growth in HEK293T and human fibroblast cells but promoting growth in U2OS cells. The combined bioactivities and pharmacokinetic properties highlight the compound's potential for therapeutic applications across a range of conditions, including depression, infectious diseases, and central nervous system disorders..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Imipramine hydrochloride (Imipramine HCl) is a first generation tricyclic antidepressant that acts primarily as an inhibitor of serotonin and norepinephrine transporters (Kds = 1.4 and 37 nM, respectively).Imipramine hydrochloride is reported to prevent the translocation of aSMase, inhibiting MV and exosomes secretion
靶点活性	5-HT:32 nM (IC50)
别名	盐酸丙米嗪, 盐酸丙咪嗪, Tofranil, Melipramine, Imipramine HCl, Imipramine (hydrochloride), G 22355

化学信息

分子量	316.87
分子式	C₁₉H₂₅ClN₂
CAS No.	113-52-0
Smiles	CN(C)CCCN1c2ccccc2CCc2ccccc21.Cl
密度	1.041g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 100 mg/mL (315.59 mM), Sonication is recommended.

H2O: 100 mg/mL (315.59 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (12.62 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.1559 mL	15.7793 mL	31.5587 mL	157.7934 mL
5 mM	0.6312 mL	3.1559 mL	6.3117 mL	31.5587 mL
10 mM	0.3156 mL	1.5779 mL	3.1559 mL	15.7793 mL
20 mM	0.1578 mL	0.7890 mL	1.5779 mL	7.8897 mL
50 mM	0.0631 mL	0.3156 mL	0.6312 mL	3.1559 mL
100 mM	0.0316 mL	0.1578 mL	0.3156 mL	1.5779 mL