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Topoisomerase II inhibitor 13

Name: Topoisomerase II inhibitor 13
Brand: TargetMol
SKU: T67899
Price: 138 CNY
Availability: InStock
Rating: 5 (10 reviews)

货号 T67899Cas号 451515-89-2 一键复制产品信息纯度: 99.84%

很棒

Topoisomerase II inhibitor 13抑制拓扑异构酶II (Topo II)，对HL-60衍生的HL-60/MX2癌细胞具有较强的抗Topo II 毒性的抗增殖活性。

Topoisomerase II inhibitor 13

一键复制产品信息

很棒

纯度: 99.84%

货号 T67899Cas号 451515-89-2

Topoisomerase II inhibitor 13抑制拓扑异构酶II (Topo II)，对HL-60衍生的HL-60/MX2癌细胞具有较强的抗Topo II 毒性的抗增殖活性。

规格	价格	库存
1 mg	¥ 138	现货
5 mg	¥ 345	现货
10 mg	¥ 553	现货
25 mg	¥ 931	现货
50 mg	¥ 1,390	现货
100 mg	¥ 2,000	现货
200 mg	¥ 2,750	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

凭借在化合物合成方面的丰富经验，我们可以根据您的研究需求为该产品提供快速定制合成服务。

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纯度: 99.84%

颜色: 黄色

性状: Solid

资源下载: COA HNMR LCMS产品操作手册

产品介绍

Topoisomerase II inhibitor 13 AI Summary

Topoisomerase II inhibitor 13 exhibits significant bioactivity against Plasmodium falciparum strains Dd2 and 3D7, with inhibition rates of 99.0% and 100.0% respectively in whole red blood cells. It has an XC50 value of 266.88 nM against Plasmodium falciparum 3D7 LDH activity and shows a lower inhibition rate of 2.0% in another LDH reporter assay. The compound also inhibits the human HepG2 cell line by 8.0% and demonstrates an Inhibition Frequency Index (IFI) of 5.52% in non-kinase HTS assays. Additionally, Topoisomerase II inhibitor 13 exhibits cytotoxicity against transgenic Leishmania Mexicana promastigotes with glucose transport deficiencies, showing inhibitory activity ranging from 4.63% to 7.13%. It has antiproliferative effects on various human cancer cell lines, including HeLa, MDA-MB-201, A549, K562, Raji, HL60, and HL60/MX2 cells, with IC50 values ranging from 1800.0 nM to 28900.0 nM after 48 hours of treatment. Furthermore, it displays an IC50 ratio of 2.5 when comparing its activity on HL60/MX2 cells to HL60 cells and exhibits cytotoxicity against HEK293 cells with an IC50 value of 7870.0 nM after 48 hours..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Topoisomerase II inhibitor 13 inhibits topoisomerase II (Topo II) that shows strong anti-proliferation activity against HL-60/MX2 cancer cells derived from HL-60 against Topo II toxicity.

化学信息

分子量	413.48
分子式	C₂₂H₂₃N₉
CAS No.	451515-89-2
Smiles	NC1=C(C=2C(N1CCCN(CC)CC)=NC(C#N)=C(C#N)N2)C=3NC=4C(N3)=CC=CC4
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 6 mg/mL (14.51 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4185 mL	12.0925 mL	24.1850 mL	120.9248 mL
5 mM	0.4837 mL	2.4185 mL	4.8370 mL	24.1850 mL
10 mM	0.2418 mL	1.2092 mL	2.4185 mL	12.0925 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。