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顶部相关产品产品介绍化学信息储存和溶解信息计算器

Amantadine hydrochloride

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纯度: 99.98%

货号 T1406Cas号 665-66-7

别名 盐酸金刚烷胺, Symmetrel, CI-719, Amantadine HCl, 1-Adamantylamine hydrochloride, 1-Adamantanamine hydrochloride, 1-adamantanamine HCl

Amantadine hydrochloride (CI-719) 是一种抗病毒药物，用于预防或对症治疗甲型流感和帕金森病。它阻断质子流通过 M2 离子通道，从而阻止病毒 RNA 释放到感染细胞的细胞质中。

Amantadine hydrochloride
其他形式的 “Amantadine hydrochloride”:
Amantadine-d6
Amantadine-d15 Hydrochloride
Amantadine hydrochloride (Standard)
Amantadine (Standard)
Gemfibrozil
Amantadine sulfate
Amantadine

Amantadine hydrochloride

一键复制产品信息
Rating icon 很棒

纯度: 99.98%

货号 T1406 别名 盐酸金刚烷胺, Symmetrel, CI-719, Amantadine HCl, 1-Adamantylamine hydrochloride, 1-Adamantanamine hydrochloride, 1-adamantanamine HClCas号 665-66-7

Amantadine hydrochloride (CI-719) 是一种抗病毒药物，用于预防或对症治疗甲型流感和帕金森病。它阻断质子流通过 M2 离子通道，从而阻止病毒 RNA 释放到感染细胞的细胞质中。

规格价格库存数量
500 mg
¥ 247
现货
5 g
¥ 493
现货
1 mL x 10 mM (in DMSO)
¥ 272
现货
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产品介绍

生物活性
产品描述
Amantadine hydrochloride (CI-719) is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A and Parkinson disease.
别名盐酸金刚烷胺, Symmetrel, CI-719, Amantadine HCl, 1-Adamantylamine hydrochloride, 1-Adamantanamine hydrochloride, 1-adamantanamine HCl
化学信息
分子量187.71
分子式C10H18ClN
CAS No.665-66-7
SmilesCl.NC12CC3CC(CC(C3)C1)C2
密度1.0276 g/cm3 (Estimated)
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
Ethanol: 36 mg/mL (191.79 mM), Sonication is recommended.
H2O: 35 mg/mL (186.46 mM), Sonication is recommended.
DMSO: 45 mg/mL (239.73 mM), Sonication is recommended.
溶液配制表
H2O/Ethanol/DMSO
1mg5mg10mg50mg
1 mM5.3274 mL26.6368 mL53.2737 mL266.3683 mL
5 mM1.0655 mL5.3274 mL10.6547 mL53.2737 mL
10 mM0.5327 mL2.6637 mL5.3274 mL26.6368 mL
20 mM0.2664 mL1.3318 mL2.6637 mL13.3184 mL
50 mM0.1065 mL0.5327 mL1.0655 mL5.3274 mL
100 mM0.0533 mL0.2664 mL0.5327 mL2.6637 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
TargetMol | Animal experiments 比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments 一共给药动物10只，您使用的配方为5%TargetMol | reagent DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent （ 母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法: 取 50μLDMSOTargetMol | reagent 母液，添加 300 μLPEG300TargetMol | reagent 混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline/PBS/ddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ， 玉米油 等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

TargetMol AI Summary
Amantadine hydrochloride exhibits a wide array of bioactivities, primarily demonstrating potent antiviral activity against various strains of influenza A virus in MDCK cells with an MIC50 of 0.5 µg/mL and a high selectivity index of 600.0, indicating strong efficacy and low toxicity. It inhibits virus-induced cytopathogenicity with an EC50 value of 49,100 nM and shows minimal cytotoxicity with an MTC greater than 1,333.0 µM. The compound also potently inhibits the influenza A virus M2 ion channel (Kd = 320.0 nM) and demonstrates effective antiviral action against H2N2 (EC50 = 1,100.0 nM) and reassortant H3N2 (EC50 < 900.0 nM) strains. Additionally, Amantadine hydrochloride exhibits moderate to low antitrypanosomal activity against Trypanosoma brucei 427 and antiplasmodial activity against Plasmodium falciparum strains 7G8 and GB4. It further shows various bioactivities, including inhibition of NMDA receptor activity in rat cerebellar granule neurons and prevention of SARS-CoV-2 induced cytotoxicity in VERO-6 and Caco-2 cells, albeit with modest effects. The compound demonstrates inhibitory activity against several bacteria and selective antifungal activity, although it lacks bioactivity against common bacterial strains like Staphylococcus aureus and Escherichia coli. Moreover, Amantadine hydrochloride has shown minimal antibacterial activity against Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, and MRSA. Among other activities, it exhibits high potency in specific cellular mechanisms such as the inhibition of Thyroid Hormone Receptor interaction, Lamin A Splicing, SMN2 Splice Variant Expression, Bloom's syndrome helicase, and DNA re-replication in SW480 colon adenocarcinoma cells..
Note: Summary generated by AI, AI may be wrong some times, we do not provide any medical advice and only sell our product to accredited institution, Please cross-check with other sources, data source: chembl

关键词

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