Complement factor D-IN-1

Name: Complement factor D-IN-1
Brand: TargetMol
SKU: T16898
Rating: 4.5 (1 reviews)

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产品编号 T16898Cas号 1386455-76-0

Complement factor D-IN-1 is an effective and selective small-molecule reversible factor d inhibitor (IC50s: 0.006 and 0.05 μM in FD Thioesterolytic Fluorescent Assay and a MAC Deposition Assay, respectively).

Complement factor D-IN-1

还可以

产品编号 T16898Cas号 1386455-76-0

规格	价格	库存	数量
5 mg	¥ 7,700	5日内发货
10 mg	¥ 10,490	5日内发货

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产品介绍

生物活性

产品描述	Complement factor D-IN-1 is an effective and selective small-molecule reversible factor d inhibitor (IC50s: 0.006 and 0.05 μM in FD Thioesterolytic Fluorescent Assay and a MAC Deposition Assay, respectively).
靶点活性	FD:0.006 μM, MAC:0.05 μM
体外活性	Complement factor D-IN-1 displays similar potency against human and monkey FD (IC50s: 0.005 μM in FD thioesterolytic assays and 0.011 μM in 50% serum MAC deposition assays for both human and monkey) [1].
体内活性	Complement factor D-IN-1 shows an excellent oral PK profile in Sprague–Dawley rats and, following an oral dose (10 mg/kg) in Brown Norway rats, demonstrates a good distribution and sustained exposure in ocular tissues including the neural retina. Mean exposure levels in plasma, the PEC, and the retina at 6 h after dosing are 0.36, 0.43, and 0.09 μM, respectively [1].

化学信息

分子量	483.32
分子式	C₂₁H₁₉BrN₆O₃
CAS No.	1386455-76-0
密度	1.82 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 250 mg/mL (517.26 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0690 mL	10.3451 mL	20.6902 mL	103.4511 mL
5 mM	0.4138 mL	2.0690 mL	4.1380 mL	20.6902 mL
10 mM	0.2069 mL	1.0345 mL	2.0690 mL	10.3451 mL
20 mM	0.1035 mL	0.5173 mL	1.0345 mL	5.1726 mL
50 mM	0.0414 mL	0.2069 mL	0.4138 mL	2.0690 mL
100 mM	0.0207 mL	0.1035 mL	0.2069 mL	1.0345 mL