Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Influenza A virus-IN-1, a dihydropyrrolidones derivative, is a highly effective inhibitor of various subtypes of influenza A virus (IAV) with IC 50 values ranging from 3.11 μM to 7.13 μM. It effectively suppresses IAV replication and enhances the expression of key antiviral cytokines, such as IFN-β, and the antiviral protein MxA.
产品描述 | Influenza A virus-IN-1, a dihydropyrrolidones derivative, is a highly effective inhibitor of various subtypes of influenza A virus (IAV) with IC 50 values ranging from 3.11 μM to 7.13 μM. It effectively suppresses IAV replication and enhances the expression of key antiviral cytokines, such as IFN-β, and the antiviral protein MxA. |
靶点活性 | A/PR/8/34 (H1N1) with NA-H274Y:6.48 μM (IC50), Influenza A virus 690 (H3):7.13 μM (IC50), A/FM-1/1/47 (H1N1):3.58 μM (IC50), A/Aichi/2/68 (H3N2):5.26 μM (IC50), A/Puerto Rico/8/34 (H1N1):3.11 μM (IC50) |
体外活性 | Influenza A virus-IN-1 (compound 5-2; 5-40 μM; 24 hours; MDCK cells) treatment significantly decreases the yields of influenza viral NP in a dose-dependent manner. And the expression level of NP protein could also be restrained in a dose-dependent manner[1]. Influenza A virus-IN-1 (compound 5-2) treatment reduces influenza HA mRNA expression at all three time points[1]. Influenza A virus-IN-1 (compound 5-2) could efficiently inhibit replication of IAV and suppress the production of the NDAPH oxidase NOX1 in MDCK cells[1]. Western Blot Analysis[1]Cell Line: IAV-infected MDCK cells Concentration: 5 μM, 10 μM, 20 μM, 40 μM Incubation Time: 24 hours Result: Significantly decreased the yields of influenza viral NP in a dose-dependent manner. |
分子量 | 534.458 |
分子式 | C27H20F6N2O3 |
CAS No. | 2250313-14-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Influenza A virus-IN-1 2250313-14-3 Influenza A virus IN 1 Influenza A virusIN1 Inhibitor inhibitor inhibit