Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PAK4-IN-2 is an exceptionally effective inhibitor of PAK4, exhibiting an IC 50 value of 2.7 nM. This compound is capable of arresting MV4-11 cells at the G0/G1 phase and inducing cell apoptosis. It holds significant potential in cancer research [1].
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 6-8周 | ||
50 mg | ¥ 13,800 | 6-8周 | ||
100 mg | ¥ 17,500 | 6-8周 |
产品描述 | PAK4-IN-2 is an exceptionally effective inhibitor of PAK4, exhibiting an IC 50 value of 2.7 nM. This compound is capable of arresting MV4-11 cells at the G0/G1 phase and inducing cell apoptosis. It holds significant potential in cancer research [1]. |
体外活性 | PAK4-IN-2 (compound 5n) (0-10 μM; 72 hours) exhibits cell growth inhibition potency in hematoma tumor MV4-11 and solid tumor cell line MDA-MB-231, shows less sensitivity in normal human renal epithelial cell 239 T cell [1]. PAK4-IN-2 (5-50 nM; 48 hours) causes a majority of cells in G0/G1 phase with decreasing S-phase populations [1]. PAK4-IN-2 (10-250 nM; 48 hours) induces apoptosis in a dose-dependent manner [1]. PAK4-IN-2 (50-800 nM; 24 hours) markedly reduces the expression levels of p-PAK4(Ser474) in concentration dependently [1]. Cell Proliferation Assay Cell Line: MV4-11, MDA-MB-231 and 293T [1] Concentration: 0-10 μM Incubation Time: 72 hours Result: Exhibited significant cell growth inhibition potency in hematoma tumor MV4-11 (IC 50 = 7.8 ± 2.8 nM), and moderate potent anti-proliferative effect in solid tumor cell line MDA-MB-231 (IC 50 = 825 ± 106 nM), less sensitivity in normal human renal epithelial cell 239 T cell (IC 50 > 10000 nM). Cell Cycle Analysis Cell Line: MV4-11 [1] Concentration: 5, 10 and 50 nM Incubation Time: 48 hours Result: Caused a majority of cells in G0/G1 phase with decreasing S-phase populations. Apoptosis Analysis Cell Line: MV4-11 [1] Concentration: 10, 50 and 250 nM Incubation Time: 48 hours Result: Induced apoptosis in a dose-dependent manner. Western Blot Analysis Cell Line: MV4-11 [1] Concentration: 50, 200 and 800 nM Incubation Time: 24 hours Result: Markedly reduced the expression levels of p-PAK4(Ser474) in concentration dependently. |
分子量 | 356.85 |
分子式 | C18H21ClN6 |
CAS No. | 2488706-33-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
PAK4-IN-2 2488706-33-6 Inhibitor inhibitor inhibit