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Coumarin 7

Name: Coumarin 7
Brand: TargetMol
SKU: T7960
Price: 235 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 香豆素-7, 香豆素7

货号 T7960Cas号 27425-55-4 一键复制产品信息纯度: 99.92%

很棒

Coumarin 7 是一种在植物中以糖苷的形式存在的香豆素激光染料。

Coumarin 7

一键复制产品信息

很棒

纯度: 99.92%

货号 T7960Cas号 27425-55-4

别名 香豆素-7, 香豆素7

Coumarin 7 是一种在植物中以糖苷的形式存在的香豆素激光染料。

规格	价格	库存
50 mg	¥ 267	现货
100 mg	¥ 333	现货
1 mL x 10 mM (in DMSO)	¥ 235	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.92%

颜色: 白色至黄色

性状: Solid

资源下载: COA HNMR HPLC 产品操作手册

产品介绍

Coumarin 7 AI Summary

Coumarin 7 exhibits a broad spectrum of bioactivities with notable antiproliferative, enzymatic, and antiviral properties. It demonstrates antiproliferative efficacy on a range of cell lines such as human U87 MG, mouse B16, human SiHa, mouse NIH3T3, and HUVEC with IC50 values ranging from 9300.0 nM to 15000.0 nM, but shows lower efficacy on human HeLa and DLD1 cell lines with IC50 values greater than 70000.0 nM. The compound also inhibits luciferase enzymes including Photinus pyralis and Renilla reniformis, achieving complete inhibition of Photinus pyralis luciferase at 0.04 µM. Additionally, it targets ubiquitin-specific proteases, Menin-MLL interaction, Lamin A splicing, BRCT-phosphoprotein interactions, Caspases, and is involved in key biochemical and cellular processes like miRNA modulation, genomic imprint erasure, hemoglobin beta chain splicing, and DNA repair inhibition. In terms of antiviral activity, Coumarin 7 is effective against X4 tropic HIV-1 clone pNL4-3 in H9 cells with an IC50 of 240.0 nM and shows low cytotoxicity with a CC50 greater than 50,000.0 nM. It also inhibits the Vif/human APOBEC3G complex with a significant fold change compared to control. Against SARS-CoV-2, the compound inhibited the 3CL-Pro protease by 22.09% at 20µM and reduced virus-induced cytotoxicity in VERO-E6 cells with an IC50 value of 360.0 nM and a high selectivity index of 91.67. Additionally, it inhibited SARS-CoV-2-induced cytopathy in EGFP-labeled monkey Vero cells with an IC50 value of 0.3531 µM. This demonstrates Coumarin 7's potent antiviral potential, along with a favorable therapeutic index..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Coumarin 7 is a natural product.
别名	香豆素-7, 香豆素7

化学信息

分子量	333.38
分子式	C₂₀H₁₉N₃O₂
CAS No.	27425-55-4
Smiles	CCN(CC)c1ccc2cc(-c3nc4ccccc4[nH]3)c(=O)oc2c1
密度	0.39 g/cm3. Temperature:20 °C.

储存&溶解度

存储

溶解度信息

DMSO: 10 mg/mL (30 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9996 mL	14.9979 mL	29.9958 mL	149.9790 mL
5 mM	0.5999 mL	2.9996 mL	5.9992 mL	29.9958 mL
10 mM	0.3000 mL	1.4998 mL	2.9996 mL	14.9979 mL
20 mM	0.1500 mL	0.7499 mL	1.4998 mL	7.4990 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。