规格

价格

库存

数量

5 mg

¥ 127

现货

10 mg

¥ 169

现货

25 mg

¥ 263

现货

50 mg

¥ 377

现货

100 mg

¥ 533

现货

500 mg

¥ 826

现货

1 g

¥ 987

现货

1 mL x 10 mM (in DMSO)

¥ 393

现货

生物活性

产品描述	Doxylamine Succinate is a pyridine derivate histamine H1 antagonist with pronounced sedative properties. Doxylamine succinate (Decapryn) competitively blocks the histamine H1 receptor and limits the typical allergic and anaphylactic responses, including bronchoconstriction, vasodilation, increased capillary permeability, and spasmodic contraction of the gastrointestinal smooth muscle, caused by actions of histamine on bronchial and gastrointestinal smooth muscles, and on capillaries. This drug also prevents histamine-induced pain and itching of the skin and mucous membranes.
体外活性	在B6C3F1小鼠体内,以Doxylamine琥珀酸盐形式,食物摄取7天或15天(饮食中含量0, 40, 375, 750, or 1500 ppm, 以游离碱Doxylamine形式)的方式考察了Doxylamine对微粒体酶活性和血清甲状腺激素水平的影响.结果发现在B6C3F1小鼠体内,Doxylamine是肝微粒体细胞色素P450?的巴比妥类诱导剂,且与Doxylamine提升了参与T4代谢的肝酶活性的假说相一致.
别名	琥珀酸多西拉敏, Decapryn

化学信息

分子量	388.46
分子式	C₂₁H₂₈N₂O₅
CAS No.	562-10-7
Smiles	OC(=O)CCC(O)=O.CN(C)CCOC(C)(C1=CC=CC=C1)C1=NC=CC=C1
密度	1.043g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 100 mg/mL (257.43 mM), Sonication is recommended.

H2O: 100 mg/mL (257.43 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (10.3 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO/H2O