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Ellagic acid

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纯度: 99.75%

货号 T0465Cas号 476-66-4

别名 鞣花酸, Gallogen, Elagostasine

Ellagic acid (Gallogen) 是一种稠合四环类天然产物,是一种有效的 CK2 抑制剂 (IC50=40 nM;Ki=20 nM),具有 ATP 竞争性。Ellagic acid 是一种抗氧化剂,也具有抗增殖活性。

Ellagic acid

Ellagic acid

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Rating icon 很棒

纯度: 99.75%

货号 T0465 别名 鞣花酸, Gallogen, ElagostasineCas号 476-66-4

Ellagic acid (Gallogen) 是一种稠合四环类天然产物,是一种有效的 CK2 抑制剂 (IC50=40 nM;Ki=20 nM),具有 ATP 竞争性。Ellagic acid 是一种抗氧化剂,也具有抗增殖活性。

规格价格库存数量
50 mg
¥ 159
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100 mg
¥ 219
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500 mg
¥ 413
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1 g
¥ 579
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5 g
¥ 1,820
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1 mL x 10 mM (in DMSO)
¥ 150
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产品介绍


Ellagic acid AI Summary
Ellagic acid is a bioactive compound with a broad range of inhibitory properties and therapeutic potential. It inhibits HIV-1 integrase with an IC50 value of 5100.0 nM, specifically targeting the 3''-preprocessing step. It also shows antimicrobial activity by inhibiting DNA gyrase supercoiling in Escherichia coli with IC50 values of 47.0 ug/mL and 3.3 ug/mL, as well as demonstrating antibacterial activity against various bacterial strains with MIC values ranging from 2.0 to 31.25 ug/mL. Additionally, Ellagic acid exhibits antiplasmodial effects against multiple strains of Plasmodium falciparum, with IC50 values from 105.0 nM to 330.0 nM, and demonstrates significant efficacy in vivo in mouse models. The compound is a potent inhibitor of various kinases, including CK2 with an IC50 of 40.0 nM, tyrosine protein kinase pp60 c-src with an IC50 of 300.0 nM, and protein kinase A with an IC50 of 600.0 nM. It also inhibits DNA polymerase eta and iota, with an IC50 of 62.0 nM for both enzymes, and has shown significant inhibition of RAT CK2, with a Ki of 20.0 nM. Furthermore, it affects multiple antioxidant enzymes and demonstrates strong antioxidant activities, such as DPPH radical scavenging (EC50 = 4.8 μg). The compound inhibits SphK1 with an IC50 of 740.0 nM, amyloid beta aggregation, various carbonic anhydrase isoforms, and multiple other enzymes and pathways, including IKKbeta, CK2alpha, and HIV1 RT. Ellagic acid also displays anti-inflammatory properties by reducing nitric oxide production in mouse RAW264.7 cells, with an IC50 value greater than 50000.0 nM. Additionally, Ellagic acid shows cytotoxic effects against cancer cell lines, such as a human cancer cell line in the NCI's anticancer drug screening program with a GI50 value of 10.0 nM, and demonstrates immunomodulatory activities. It also exhibits antiviral activity against SARS-CoV-2, EBOV, and MARV with respective IC50 values, and inhibits enzymes like maltase dehydrogenase, chymotrypsin, and cruzain. Ellagic acid is soluble in water at 9.7 ug/mL and has documented effects on glucose uptake in 3T3 L1 adipocytes, extending its potential applications as a therapeutic agent..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
Ellagic acid (Gallogen), a thickened tetracyclic natural product, is a potent CK2 inhibitor (IC50=40 nM; Ki=20 nM) with ATP-competitive properties. Ellagic acid is an antioxidant and also possesses antiproliferative activity.
靶点活性
CK2:40 nM
体外活性

方法: 人胰腺癌细胞系 PANC-1、AsPC-1 和 MIA PaCA-2 用 Ellagic acid (10-1000 µM) 处理 24-72 h,使用 MTT assay 检测细胞活力。
结果: 添加 10 µM Ellagic acid 后,PANC-1 的增殖受到抑制,其抑制作用呈剂量依赖性。添加 100 µM Ellagic acid 后,AsPC-1 增殖受到抑制,而 MIA PaCA-2 增殖仅在添加 1000 µM Ellagic acid 后受到抑制。[1]
方法: 人肺癌细胞 A549 用 Ellagic acid (5-20 µM) 处理 48 h,使用 Western Blot 检测靶点蛋白表达水平。
结果: Ellagic acid 处理显著下调了 PI3K 和 Akt 的磷酸化,且呈剂量依赖性。[2]

体内活性

方法: 为研究对酒精诱导的肝病 (ALD) 的肝脏保护作用,将 Ellagic acid (50-100 mg/kg suspended in 0.5% CMC-Na) 灌胃给药给每日口服 50% (v/v) 酒精的 ICR 小鼠,每天一次,持续四周。
结果: Ellagic acid 减轻了 ALD 小鼠的氧化应激、炎症反应、脂肪变性和肠道微生物群失调。[3]

别名鞣花酸, Gallogen, Elagostasine
化学信息
分子量302.19
分子式C14H6O8
CAS No.476-66-4
SmilesOC1=CC2=C3C(OC(=O)C4=CC(O)=C(O)C(OC2=O)=C34)=C1O
密度1.667 g/cm3
储存&溶解度
存储In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
DMSO: 3.03 mg/mL (10.03 mM), Sonication is recommended.
体内实验配方
10% DMSO+90% Saline: 0.15 mg/mL (0.5 mM), Solution.
请按顺序添加溶剂,在添加下一种溶剂之前,尽可能使溶液澄清。如有必要,可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考,体内配方并不是绝对的,请根据不同情况进行调整。
溶液配制表
DMSO
1mg5mg10mg50mg
1 mM3.3092 mL16.5459 mL33.0918 mL165.4588 mL
5 mM0.6618 mL3.3092 mL6.6184 mL33.0918 mL
10 mM0.3309 mL1.6546 mL3.3092 mL16.5459 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法:
比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL, 一共给药动物10只,您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O, 那么您的工作液浓度为2 mg/mL
母液配置方法:2 mg 药物溶于 100 μL DMSO ( 母液浓度为 20 mg/mL ), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:100 μL DMSO 母液, 添加 400 μL PEG300 混匀澄清, 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。
方案所需的各类助溶剂如: DMSOPEG300PEG400Tween 80SBE-β-CD玉米油等, 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算,您也可以参考 更多

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