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免疫/炎症分子化合物库

免疫/炎症分子化合物库

产品编号 L4700 Immunology/Inflammation Compound Library
  库化合物信息   Excel SDF

当某些触发因素引起免疫系统功能紊乱,使其不能区分正常组织和病原,开始攻击破坏自身正常组织时,就会发生自身免疫性疾病,受累部位包括血管、结缔组织、关节和皮肤等。随着19-20世纪的化学进展,开发了非甾体抗炎药(NSAIDs),尽管有效治疗炎性疾病,但NSAID 具有一些不良作用,例如溃疡,肾损伤和胃肠道出血。后来虽然被描述为抗肿瘤介质,但肿瘤坏死因子-α(TNF)通常被认为是主要的促炎细胞因子。它在炎性疾病的发病机制中起关键作用,因此,抗TNF 治疗已成为治疗自身免疫性疾病的主要方法。随着基础研究的快速进展,许多与自身免疫性疾病相关的信号传导途径及相关蛋白陆续被发现,这些蛋白是潜在治疗免疫性疾病的药物靶点,例如,很多小分子化合物或基于大环的药物具有抑制免疫蛋白酶体、抑制核输出蛋白、抑制 NF-kB 和肿瘤坏死因子-α(TNF)的活性,这些化合物有可能发展成用于治疗自身免疫疾病和慢性炎症疾病的药物。 TargetMol 免疫/炎症分子化合物库包含了4720 个抗炎活性化合物,用于抗免疫疾病药物高通量筛选,确认药物靶点以及其他医药研发和科研领域。

TargetMol的所有产品和服务仅用于科学研究,不能被用于人体,我们也不向个人提供产品和服务。
TargetMol Compound Library
规格
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
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产品描述

  • 4720种具有抗炎症活性的化合物的特有集合,可用于高通量筛选和高内涵筛选;
  • 部分化合物已经得到FDA批准上市;
  • 结构多样,药效显著,可渗透细胞;
  • 详细的说明书,化合物结构、靶点信息、IC50值、活性描述等;
  • NMR、HPLC/LCMS等多种检测技术保证产品结构正确,纯度高,减少假阳性。

化合物库定制

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包装和存储

  • 干粉或者DMSO溶液置于带二维码的储存管中,或排列于96孔板/384孔板;
  • 蓝冰运输
获取筛选库化合物信息 (L4700)
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化合物库组成

Apoptosis (498)
Antibacterial (431)
Autophagy (380)
Antibiotic (329)
COX (273)
NF-κB (257)
Endogenous Metabolite (254)
EGFR (191)
Reactive Oxygen Species (179)
Histamine Receptor (175)
HIV Protease (128)
Antifungal (121)
Parasite (112)
JAK (112)
ERK (104)
p38 MAPK (102)
Prostaglandin Receptor (99)
TNF (96)
IL Receptor (92)
STAT (90)
AMPK (84)
NO Synthase (82)
Raf (81)
Antiviral (77)
5-HT Receptor (76)
Antioxidant (76)
Influenza Virus (74)
Ras (74)
AChR (68)
DNA/RNA Synthesis (68)
TLR (67)
ROS (65)
Akt (63)
Adrenergic Receptor (62)
CDK (60)
MAPK (56)
P450 (56)
JNK (54)
PI3K (54)
PDE (54)
NOS (53)
Nrf2 (52)
CCR (49)
Ferroptosis (49)
Glucocorticoid Receptor (49)
MEK (49)
VEGFR (49)
HER (48)
PPAR (46)
SARS-CoV (46)
Calcium Channel (45)
Lipoxygenase (45)
IκB/IKK (45)
Interleukin (44)
HCV Protease (44)
Potassium Channel (43)
Immunology/Inflammation related (43)
CXCR (40)
GSK-3 (40)
FLT (40)
MMP (39)
Virus Protease (39)
Caspase (39)
Src (37)
Tyrosine Kinases (37)
Dehydrogenase (37)
HBV (33)
Dopamine Receptor (33)
Reverse Transcriptase (33)
HSV (32)
PKC (32)
S6 Kinase (32)
RIP kinase (31)
NOD (31)
BTK (31)
AChE (31)
Topoisomerase (30)
mTOR (29)
Mitophagy (28)
Antifection (28)
GPR (27)
Phospholipase (27)
GABA Receptor (27)
ribosome (26)
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AhR (20)
S1P Receptor (20)
LTR (20)
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c-Kit (18)
LPL Receptor (18)
PD-1/PD-L1 (17)
HIF/HIF Prolyl-Hydroxylase (17)
PKA (17)
Tyrosinase (17)
NOD-like Receptor (NLR) (17)
ATPase (17)
Casein Kinase (17)
Sirtuin (17)
Anti-infection (17)
Rho (16)
Bcr-Abl (16)
Mitochondrial Metabolism (16)
PARP (16)
Opioid Receptor (16)
RAAS (16)
Drug Metabolite (15)
Microtubule Associated (15)
IGF-1R (15)
P-gp (15)
Integrin (15)
Serine Protease (15)
PGE Synthase (14)
Estrogen Receptor/ERR (14)
Histone Methyltransferase (14)
MAO (14)
Norepinephrine (13)
NADPH (13)
NADPH-oxidase (13)
Thrombin (13)
ALK (12)
c-RET (12)
P2X Receptor (12)
c-Fms (11)
P2Y Receptor (11)
Indoleamine 2,3-Dioxygenase (IDO) (11)
Proton pump (11)
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p53 (11)
c-Met/HGFR (10)
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transporter (8)
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Epoxide Hydrolase (7)
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FXR (7)
Free radical scavengers (7)
Serotonin Transporter (7)
ASK (7)
Arginase (7)
Chloride channel (7)
Glucosidase (7)
Sigma receptor (7)
Transferase (6)
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PAFR (4)
LDL (4)
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Telomerase (4)
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AIM2 (3)
Neurokinin receptor (3)
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Guanylate cyclase (3)
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DNA Methyltransferase (3)
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RANKL/RANK (3)
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PAK (3)
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KLF (3)
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CD38 (3)
Adenosine deaminase (3)
Liver X Receptor (3)
Acyltransferase (3)
PKM (3)
Arrestin (3)
LRRK2 (3)
GPCR19 (3)
ABC (3)
Imidazoline Receptor (2)
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advanced glycation end products (2)
Oxytocin Receptor (2)
Dynamin (2)
Adenylyl cyclase (2)
EBI2/GPR183 (2)
Gap Junction Protein (2)
NPC1L1 (2)
Hydroxylase (2)
PLK (2)
Thyroid hormone receptor(THR) (2)
OAT (2)
PI4K (2)
Glutathione reductase (2)
Glucokinase (2)
Glutaminase (2)
cell cycle arrest (2)
Integrase (2)
Melatonin Receptor (2)
ACK (2)
Tie-2 (2)
ATP Citrate Lyase (2)
RAR/RXR  (2)
Endothelin Receptor (2)
Hippo pathway (2)
GST (2)
MELK (2)
RXFP receptor (1)
Glucagon Receptor (1)
PROTAC Linker (1)
Anion Exchanger (1)
TAM Receptor (1)
N-Acetylglucosaminyltransferase (1)
CaSR (1)
Na-K-Cl cotransporter (1)
GlyT (1)
AAK1 (AP2 associated kinase 1) (1)
MT Receptor (1)
Mdm2 (1)
PACAP (1)
OCT (1)
GNRH Receptor (1)
CFTR (1)
Haspin Kinase (1)
Adiponectin receptor (1)
Amylase (1)
GPX (1)
YAP (1)
Kinesin (1)
PYK2 (1)
CRM1 (1)
Neurotensin Receptor (1)
MAGL (1)
BMI-1 (1)
Taste receptor (1)
Necroptosis (1)
Na+/Ca2+ Exchanger (1)
Survivin (1)
hCE (1)
CRFR (1)
Beta-Secretase (1)
OXPHOS (1)
CGRP Receptor (1)
BCRP (1)
Hydrogenase (1)
stilbene oxidase (1)
Monocarboxylate transporter (1)
Methionine Adenosyltransferase (MAT) (1)
GluCls (1)
DAPK (1)
PAD (1)
OX Receptor (1)
Somatostatin (1)
GSNOR (1)
Protease (1)
Vasopressin Receptor (1)
VDA (1)
Neprilysin (1)
Bombesin Receptor (1)
Melanin-concentrating Hormone Receptor (MCHR) (1)
LIM Kinase (1)

化合物库信息示例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE
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