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DIM-C-pPhOH

Name: DIM-C-pPhOH
Brand: TargetMol
SKU: T4400
Price: 273 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.93%

货号 T4400Cas号 151358-47-3

别名 CDIM8

DIM-C-pPhOH (CDIM8) 是一种核受体 4A1(NR4A1) 拮抗剂，可降低细胞增殖，对 ACHN 细胞和 786-O 细胞的IC50值分别为 13.6 μM 和 13.0 μM。它抑制癌细胞的生长和 mTOR 信号传导，诱导细胞凋亡和细胞应激。

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DIM-C-pPhOH

一键复制产品信息

很棒

纯度: 99.93%

货号 T4400 别名 CDIM8Cas号 151358-47-3

规格	价格	库存
1 mg	¥ 273	现货
2 mg	¥ 389	现货
5 mg	¥ 622	现货
10 mg	¥ 788	现货
25 mg	¥ 1,570	现货
50 mg	¥ 2,390	现货
100 mg	¥ 3,590	现货
200 mg	¥ 5,150	现货
1 mL x 10 mM (in DMSO)	¥ 683	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.93%

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COA HNMR LCMS 产品操作手册

产品介绍

DIM-C-pPhOH AI Summary

DIM-C-pPhOH induces cell cycle arrest in human MCF7 cells and affects cell cycle progression at various concentrations (2 µM, 4 µM, 8 µM), causing accumulations in different phases (G0, G1, S, G2/M) after 24 hours. The compound also exhibits significant antileishmanial activity against Leishmania donovani, with IC50 values ranging from 51,330 nM to 92,840 nM and IC90 values from 88,880 nM to 106,400 nM. Additionally, it has antibacterial activity against methicillin-resistant Staphylococcus aureus and Staphylococcus aureus, with MIC values between 29,590 nM and 59,200 nM, and IC50 values from 10,470 nM to 17,810 nM. Its antifungal activity against Cryptococcus neoformans is marked by MIC values at 59.17 µM and 29,590 nM, and IC50 values at 18,910 nM. DIM-C-pPhOH also demonstrates agonist activity at the human GPR84 receptor in CHO cells, inhibiting forskolin-induced cAMP accumulation (EC50 >10000 nM, Emax 7.0% at 10 µM) and affecting beta-arrestin recruitment (EC50 >10000 nM, Emax -5.0% at 10 µM)..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	DIM-C-pPhOH (CDIM8) is a nur77 (NR4A1) antagonist,inhibits TGF-β induced cell migration of breast cancer cell lines,promotes ROS/endoplasmic reticulum stress and proapoptotic pathways in pancreatic cancer cell lines,mimics effects of Nur77 RNAi silencing.
靶点活性	Nur77:NA
别名	CDIM8

化学信息

分子量	338.4
分子式	C₂₃H₁₈N₂O
CAS No.	151358-47-3
Smiles	Oc1ccc(cc1)C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
密度	1.321 g/cm3 (Predicted)
颜色	Red
物理性状	Solid

储存&溶解度

存储

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 33.84 mg/mL (100 mM), Sonication is recommended.

Ethanol: 33.84 mg/mL (100 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.91 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.9551 mL	14.7754 mL	29.5508 mL	147.7541 mL
5 mM	0.5910 mL	2.9551 mL	5.9102 mL	29.5508 mL
10 mM	0.2955 mL	1.4775 mL	2.9551 mL	14.7754 mL
20 mM	0.1478 mL	0.7388 mL	1.4775 mL	7.3877 mL
50 mM	0.0591 mL	0.2955 mL	0.5910 mL	2.9551 mL
100 mM	0.0296 mL	0.1478 mL	0.2955 mL	1.4775 mL